‘Old Person smell..kareishu – is real. Can rapamycin help?

Let’s just pile on to the shit show of getting old. As if skin deterioration, arthritis, inflammaging and functional decline isn’t enough I bring you
Kareishu - https://tiphero.com/old-person-smell.

Now I bring this up because when some friends who mentioned on this website their pet Wally had hit the ripe old dog age of 15 years - 105 human years… the dog layed in its warming bed and smelled bad even for a dog. Like decay… everything was drying out slowly. But within a few months of rapamycin treatment 2mg every week. Wally’s fur became shiney and the decay scent vanished. Wally went on to regain a cool wet moistured nose and all kinds of of benefits such as improved limb movement and mental curiosity. That was two years ago, the most recent Wally update was actually a video. He was swimming around a pool… now the human equivalent of 119 years. Wally continues to smell healthy under his weekly rapamycin dosing.

As a side note to a side note… lol. A physician friend had a duck hunting black labrador at the age of 10, I guess that’s 70 human years. Buddy had slowed down in his ability to do the annual family hunt. Usually a four day duck hunting trip. I recommended - and supplied them with enough rapamycin to dose 2mg every four days at the end of two months (1 year and 2 months human years equivalent), the dog rocked its hunting trip and outperformed the younger labradors.

Here’s what I received from them in an email while I was in Australia this week. I had asked for an update.

Jason, your timing is incredible! my husband literally got home from his annual week up at “duck camp” with Buddy late last night. Then worked all day today, he and I finally debriefed and I literally said, “we have to email Jason to update him!”

Yes, we noticed a significant improvement in Buddy’s energy level! It really is quite remarkable! Even my husband’s 2 brothers (who also have labs) commented that Buddy seems to have turned back the clock! So it is definitely working!

And we felt like he seemed to have some more energy and playfulness overall, but hunting for 4 days straight was really a big test. It’s pretty remarkable!

We had stopped into talk to our vet about it shortly after we got back from visiting with you… Our vet had never heard of it, but seemed open to learning a bit about it. He did look at his suppliers at that point, but didn’t see rapamycin available from his current suppliers. My husband is going to follow up with our vet again after witnessing Buddy’s hunting experience.

But right now, we are still on the hunt for a supplier. I haven’t looked at whole lot into the ones on rapamycin.news yet, as we were hoping we could get it through our vet first. But the clock is starting to tick! Your generous supply runs out Nov. 10! Maybe they sell it OTC in Australia??!! :wink:

Have a great trip! I’ll keep you posted with any further developments!

G’day Mate!
Buddy’s family

If you have an old dog, put them on rapamycin… i now have N=2 on my dog rejuvenation success!

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@Agetron

Now the question is - Are the humans in the family going to try Rapamycin?

You also may want to give them a trusted Indian contact. :slight_smile:

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Oh definitely Chris!

Although only in their forties, they’re considering it for themselves and for their parents.

Turning your pet dog’s health around. There’s a lot of evidence for a physician that might be doubtful of the miracle molecule rapamycin.

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The 40s are a great time to start. I’d even hazard that the 30s aren’t a bad time to start either!

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The “old person smell” may be due to the increase in 2-nonenal.

https://www.jidonline.org/article/S0022-202X(15)41198-4/fulltext

Human body odor consists of various kinds of odor components. Here, we have investigated the changes in body odor associated with aging. The body odor of subjects between the ages of 26 and 75 was analyzed by headspace gas chromatography/mass spectrometry. 2-Nonenal, an unsaturated aldehyde with an unpleasant greasy and grassy odor, was detected only in older subjects (40 y or older). [Journal of Investigative Dermatology]

A Derma website (area code 775 Nevada) is marketing a solution - persimmon soap, claimed to be of Japanese inspiration Website states the founder is Koko Hayashi.

Nonenal, Odor Eliminating Soap – Mirai Clinical.

Persimmon Extract (or tannin) dissolves nonenal, thereby eliminating its odor. Persimmon fruit is a potent antiseptic loaded with vitamins and has been used by the Japanese for its naturally purifying and deodorizing benefits.

Amazon has it - $21 for a bar of soap of 3.53 ounces.

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Thanks, Juan for the follow-up, post. I think was a great simple description of the process and what the problem is.

I’m surprised that it happens starting at 40, but just as when my son turned into a teen - hit puberty and his male hormones went off the charts, and you could literally smell the testosterone when you opened up the door to his room or picked up his dirty laundry. . No different than when you enter a nursing home, the human scent it is incredibly potent.

And, here’s one more of my side notes. Dogs have the ability to actually smell cancers within human bodies. They actually did some different tests where dogs can locate the disease by scent. Much like finding that apple in your backpack, when you’re going through security at the airport. How??

As dogs themselves grow older… physically changing, when put on rapamycin, can they sense the changing scent within themselves… as cells regenerate, because they really do start feeling better. And, I know Wally looks forward to his rapamycin dose. The dog seems to know what it is… and is very happy to get it.

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