NPR - another mainstream news report on rapamycin. This might get the news out on this longevity medication.
Glad I have stocked up for 4-years worth of medication.
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Geez…more evidence that people on this forum are NOT normal…reminds me of survivalists hoarding guns…or toilet paper or bottled water. I can just imagine the police breaking down the door to investigate reports that you have an illegal portrait of Dorian Gray…“well, I don’t see any weapons…but, look, here’s a whole roomful of rapamycins!”
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Hahaha… I have to agree with you Mike.
Anyone looking to reverse, stall or extend their years is not considered normal. Welcome to the rapamycin.news forum.
I am familiar with supply and demand marketing. If rapamycin use hits a certain velocity… it might be harder or impossible to get.
I never expected that baby formula, or diapers or toilet paper would be something you couldn’t get at all… and those are basic items.
My supply of rapamycin has grown slowly a few pills each month – thanks to extending my dose with GFJ over the past 4-years. Now I am going pure rapamycin 4 mg no GFJ for the next 6 months and then testing my bio-markers. Moderate might be better… at least for me.
Last… hands off the Dorian Gray painting hidden… up in my attic - Lol
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My pharmacy cannot obtain Rapamune, 0.5 mg anymore, even though it’s prescribed to me. They just offered Sirolimus 0.5 mg instead, blaming Pfizer for that. It’s not a good sign. I still receive 1mg Rapamune from them, but worry that it will also end soon and will be substituted by generic Sirolimus.
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How do you store it? Do you refrigerate it?
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From the packaging for Sirolimus 1mg tablets (Biocon)…
“Storage: store protected from moisture at a temperature not exceeding 30°C…”
Seems pretty straight forward…
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I keep mine - like Dr. Surendra Nath Sehgal, PhD - In glass bottles - in an ice cream tub - in my freezer - with a note on top that says: DO NOT EAT!! His rapamycin was just as potent after 5-years.
If you have not heard the story of Suren - you should take a listen: The Dirty Drug and the Ice Cream Tub
Actually, just in a large vitamin container with drying salt packets to keep moisture out in the freezer.
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If there is ever significantly increased demand, it will probably be met by increased production from opportunistic Indian drug companies.
GLP-1 production in China has exploded due to demand, and the competition has driven prices down and quality up. (I have 9-years of tirzepatide vials vacuum sealed in a chest freezer with generator backup!)
Rapamycin isn’t in the same league as weight loss drugs, though. People want to look good quickly, not spend money on something that may or may not pay off many years into the future. If we ever have a supply problem, it will be because of reduced demand or nation-state actions designed to curb international shipping.
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I do think that you are right.
What keeps rapamycin somewhat expensive - inspite of it being off patent and in generic forms is the creation. It is an involved process to create from a microbe: The natural product rapamycin, produced during fermentation by Streptomyces hygroscopicus microbe, is known for its potent antifungal, immunosuppressive, and anticancer activities.
Which might cause a delay in access through its creation and supply. Some people might want to lose weight. Whereas, many might want to live longer and healthier!
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Don’t get me wrong, I’m in favor of stockpiling everything. COVID made peppers look like geniuses for a few weeks…
I just don’t think most people genuinely care about being healthy and living a long time. A lot of people can’t even be bothered to continue their cheap maintenance medications or walk 15 minutes a day. By “genuinely care” I mean that they take deliberate, regular actions to prolong their healthspan and lifespan.
If rapamycin were as easy to get as Tylenol, a few high profile celebs started to Benjamin Button, and the mainstream media talked about it non-stop for 2-years straight, then we’d have a problem.
But maybe it’s not such a bad thing that people tend to be short sided and superficial and will prioritize what they might think of as cosmetic drugs. The rapid action and obvious results of GLP-1s are the incentives that will probably result in a lot more benefits for the average (overweight) person’s lifespan than rapamycin will.
I’d like to see the ITP use obese mice with genetically overactive ghrelin production as a control group. Then put one arm on semaglutide or tirzepatide and another arm on rapamycin. See which group lives longer. My money is on the GLPs.
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They already did a study of Rapamycin on diabetic mice (which obese mice certainly are). These mice had SHORTER lifespans and died due to inflammatory diseases instead of by cancer as they normally do. This means that obese/diabetic mice and individuals probably shouldn’t take Rapamycin.
Which means a good chunk of the American population will not benefit from Rapamycin and may experience a detriment.
You need to be at a minimum non-diabetic to have gains from Rapamycin. This is also why Rapamycin is paired with Metformin and/or Acarbose for maximal gains.
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Actually you are right… easy to take for granted that we all have the potential for healthier living - but few make the little effort. We are in a culture of what pill or shot will let me continue on with my bad and lazy habits. Hahaha - I am constantly shaking my head - thinking your choice. I was there for decades too. I finally saw change was better and rapamycin even better - better!
Once at the point of no return - people want a redo! Missed opportunities.
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Yes. People tend to get health conscious after a major health disorder is developed.
But then again, look at how many people are morbidly obese and not doing anything about it.
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