“When compared to separate peer-reviewed studies using similar endpoints, the magnitude of change falls within ranges typically associated with intensive lifestyle interventions, like exercise (including High Intensity Interval Training), Mediterranean and DASH diets, and dramatic weight loss (>10% body weight loss), and exceeds what is commonly reported in most supplement studies. That’s not typical in nutrition research.“
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Link to paper and abstract https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278. Kinda weird to see it published in ssrn, usually I see papers on economics and sociology published there
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Assuming the effect is real (and not somehow a doctored study to get the desired results), I asked Google search which ingredients most likely contributed to the cardiovascular effects, and it said:
Based on evidence for reducing mortality, preventing atherosclerosis, and reducing arterial stiffness, Glucosamine Sulfate and Fisetin likely have the biggest positive effect on cardiovascular health among the listed options. Studies show glucosamine reduces cardiovascular death risk by up to 22%, while Fisetin combats vascular aging and calcification.
Here is a breakdown of the top contenders based on cardiovascular impact:
- Glucosamine Sulfate Large studies link its use to significantly lower risks of cardiovascular disease and mortality, likely due to reduced inflammation and improved blood vessel health.
- Fisetin As a potent senolytic, it clears “zombie” cells, reduces arterial stiffness, and protects against heart damage.
- [Glycine] Associated with lower risks of cardiovascular disease and improved cardiometabolic function, including reduced blood pressure and improved blood lipids.
- [Calcium Alpha-Ketoglutarate] Known for protecting heart tissue from damage and improving mitochondrial health in the cardiovascular system.
- [Magnesium Malate]: Magnesium is crucial for blood pressure regulation, vascular tone, and heart function.
Conclusion: For direct, statistically significant, long-term cardiovascular mortality reduction, > Glucosamine Sulfate is a leading choice, followed closely by Fisetin for vascular anti-aging effects.
And it’s worth pointing out that Glucosamine is being tested by the Interventions Testing Program as part of their 2025 cohort.
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I don’t understand. Their product is a mix of supplements and they brag that the improvements are across all endpoints. That shouldn’t be surprising at all! I wouldn’t use that as “we are reversing aging itself” as the article seems to say.