Nov 10: The combo of Partial Reprogramming and mTOR Inhibition

Rapamycin Longevity Lab is step by step taking the mTOR inhibition pathway to the next level 🙏 On November 10 we will co‑host an online event that kicks off launching week on Pump Science. Rapamycin Longevity, in partnership with Reprogramming Lab, will introduce three pioneering interventions on Pump Science throughout that week. We begin the event with a live launch of a chemical partial reprogramming intervention. A cutting‑edge longevity intervention aimed at reversing cellular age. During the event we will explain what partial reprogramming is and why combining it with mTOR inhibition opens an exciting path to explore. Pump Science founder Benji Leibowitz will present the platform and how it both can accelerate longevity research and enable new ways to fund it. We will also feature a lightning talk on the potential of DeSci for longevity, and Nathan Cheng, founder of the Longevity Biotech Fellowship, will share the organization’s important mission to solve aging. It’s a free online event and you can register to the event through this registration link.

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Much exciting news was highlighted last week around partial reprogramming from different biotech companies. This is a really fascinating longevity intervention which is about reversing old cells into more youthful states. Many years ago researchers discovered something like a “rewind button” in our cells. With the help of reprogramming we can press that button to reverse the age of a cell to a younger and healthier state. It’s possible to reverse cellular age back to basically age zero but to rewind cellular age this much is not optimal and can lead to uncontrolled cell division, loss of cellular identity and function. Different biotech companies and labs have therefore been working on techniques to partially reverse cellular age and by minimizing potential risks. This is what partial reprogramming is all about. In the future, this approach may help us recover more fully from injuries, reverse grey hair, wrinkles, functional decline and age-related diseases and in doing so keep us in a youthful state. It’s like being 90 but with the vitality and appearance of a 30‑year‑old.

Here is an interesting overview around the difference between genetic and chemical partial reprogramming. Rapamycin Longevity Lab together with Reprogramming Lab will push forward the research around chemical partial reprogramming and combine it with a mTOR inhibitor such as Rapamycin or Omipalisib.

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