Thanks @desertshores It seems Creatine Nitrate may be the better supplement. I’ll give it a go.
I am doing the most recommended and upping daily folate (2000mcg DFE), B6 (40mg) and B12 (400 mcg) above the multivit. but that still isn’t that much.
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One thing that might reduce homocysteine is methionine restriction, since methionine supplementation increases homocysteine. [ref] Methionine restriction also extends lifespan in male mice, even relative to long-lived controls. [ref]
One way to restrict methionine is using collagen for 35% of your protein intake, which should reduce methionine intake by 30%, while not resulting in any amino deficiencies. [ref—conflict of interest?] This also will reduce isoleucine intake by about 30%, and isoleucine restriction in mice also increases lifespan. [ref] Unfortunately we don’t know the combined effect of methionine and isoleucine restriction in mice.
Collagen also is high in glycine which extends lifespan in ITP. [ref] In rats, glycine supplementation blunts increases in circulating homocysteine caused by methionine supplementation. [ref]
Something to mention is that 3 months of methionine restriction in rats actually increases homocysteine by 2.5x. [ref] I wouldn’t worry too much about that, since I trust the mice lifespan data on methionine restriction more than I trust the negative health outcome associations with homocysteine in humans.
You can also try switching to niacin. Acutely at least, it appears to produce weaker homocysteine increase than nicotinamide [ref], which is what NMN is mostly degraded to prior to tissue uptake.
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I do take 10g of collagen/day. Both for the extra glycine (also take GlyNac) and I’ve seen improvements in my skin.I’m relatively low cal and low carb and do eat meat.
I am going to try switching to niacin (nicotinic acid) as my NMN runs out.
I’m also interested in 1-MNA as discussed by @Elizabeth here:
https://www.rapamycin.news/t/niacin-revisited-helpful-or-harmful-in-cardiac-health/12263/43?u=ng0rge
And here:
https://www.rapamycin.news/t/niacin-revisited-helpful-or-harmful-in-cardiac-health/12263/149?u=ng0rge
And by @RapAdmin here:
https://www.rapamycin.news/t/can-you-share-your-longevity-healthspan-regime/1734/456?u=ng0rge
Here’s a link to the product. Too bad it’s so expensive.
https://ohphealth.com/products/endoteliol-1mna?variant=44143499739427
"Edotelio 1-MNA is a groundbreaking molecule that has shown promising results in blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is implicated in various conditions such as metabolic health, brain health, and cellular health. By blocking NNMT, NAD levels can be optimized safely.
1-MNA, which stands for 1-methylnicotinamide, is a natural byproduct of nicotinic acid and nicotinamide, both primary variants of vitamin B3. Along with optimizing NAD levels, research indicates that 1-MNA is anti-inflammatory and plays a role in supporting the health of the vascular endothelium and the cardiovascular system. Given its potential benefits, 1-MNA can be considered a daily supplement for most individuals."
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According to the latest NMN study sponsored by Sinclair’s company, NMN is useless for males but useful for females.
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Interesting paper w/ implications for NMN and cancer. They show that NMN drives tumor immune escape by driving PD-L1 expression via IFNγ-STAT1. This sounds all bad, but IFNγ-STAT1 has broad effects on tumor-immune interactions, such that “NAD+ augmentation enhances the efficacy of anti-PD-L1 antibody in immunotherapy-resistant tumors”
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My N=1 Double Blind NR experiment. I have been taking Tru Niagen for at least 8 years. I tried starting/stopping a few times to try to gauge the benefit. It appeared to give me more energy but obviously The Placebo Force is strong so there was doubt. Amazon provided me a nice experiment by selling me a counterfeit 90 day batch that fooled me for a while. After taking the fake NR for 3 or 4 weeks I noticed an energy and workout drop off. Reflecting on “what changed?” I noticed the fake NR pills were slightly different and recalled a change in safety packaging. I confirmed the fake lot and buy direct from source since. I’m confident there is some benefit for me.
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Anyone noticed that NR, NMN, Nicotinamide increase homocysteine level? It’s especially true withMTHFR mutation.
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I get a good price on NMN from iHerb. Hard to say if it is worth taking but I currently take it.
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