I think that besides safety, the study showed that nmn supplementation raises Nad levels in circulation. Whether that translates into more cellular Nad levels is another issue.
It’s funny how a study that set out to show longevity and health benefits fell so short.
It was a half-assed study that showed a good point - that blood levels of NAD are increased. The aging calculator and 6MWT were useless though. You’d think if they were going to spend money, they’d get this part right.
I’m not saying NMN doesn’t work. I’m saying its use in humans hasn’t been clearly proven. Even the authors of that paper, in the last line, use the word “may”. As in maybe.
Data from isotope-labeled compounds revealed that the majority of absorbed NMN undergoes degradation to nicotinamide and NR before being utilized for NAD+ synthesis. Nicotinamide salvage pathway for NAD+ biosynthesis was the dominant pathway in almost all tissues except for the kidney.
Dont waste your money on NMN, just take nicotinamide, its cheaper
Matt Kaeberlein says neither NMN or NR is likely to be effective. That’s good enough for me. I take Niacin (i love the flush).
Citation please? Big fan of Kaeberlein, but cf… Just started looking into NMN/NR
Boosting NAD+ levels is one thing. Taking NMN or NR is another. Likely the NMN or NR are not actually boosting NAD+ levels. Check out one doctor’s review of recent studies.
https://twitter.com/BradStanfieldMD/status/1693383856517452056?s=20
I hear you. It’s not settled by any means given it’s basically mouse studies, David Sinclair and hopeful research as below.
However, there is this very amusing YouTube presentation of a Dr. railing against NMN and all of the responses underneath providing empirical personal evidence to in support of NMN, maybe placebo but clearly these folks are finding benefits.
There have been, I believe 12-14 human studies which established at least marginal benefit and no detriment.
I could bottle not-toxic weed killer and sell it as a life extender and 30 - 40% of the people would think it was great. 
I have used the Jinfiniti test several times to measure my NAD levels. I have taken NMN via supplements from both Jinfiniti and ProHealth Longevity, as well as NR from Niagen. Assuming (only) that the Jinfiniti test is directionally accurate, I have found that supplementing with NMN (250mg - 500mg 2x daily) has definitely raised my NAD level. Since I don’t stop and start these interventions, I hesitate to attribute energy levels etc. to any one factor, but my overall health and energy levels have been very good, at age 72. Based simply on what is known about the role of NAD in mitochondrial function and cellular energy production, I believe the value of improving intracellular NAD levels as we age is pretty clear. Based on a wide range of published studies and my own experience, I’m pretty sure that systemically supplementing with NMN and/or NR will raise NAD levels.
True dat. Although there does seem to be a lot of long term NMN users that responded to her YouTube video describing length of use/benefits. If the old people weren’t happy you’d hear about it.
Tahodenizen, really appreciate you jumping in & sharing your real-life experience with NMN/NR
With gratitude, Oaklandgrrl.
Michael Lustgarten’s N = 1. He compared NMN with niacin, P5P, and grape seed powder.
Comparison chart at 3:07.
So based on his research, niacin is the winner in an n-1 trial.
This is an area of much controversy. Searching Youtube will give you results from educated people on either side of the conversation regarding NMN. I spent a lot of money on NMN supplements that were tested for having the amount of NMN that they claimed. After several months of having no subjective benefit, I stopped taking NMN. Based on my own reading, I have opted for exercise, and the supplements tryptophan and niacinamide to boost my NAD levels, if indeed they need boosting. I don’t use niacin because I’m not too fond of the side effects. I react with unpleasant flushing even in small amounts and I can feel even the timed released versions.
You’re correct about there being a dozen or so studies, but wrong about there being any notable benefit. The detriment is wasted money that could have been spent on more proven supplements.
NMN is going to be gone from the U.S market with a high probability soon, so stock up if you want it.
Source: MisterYouAreSoDumb comments on So should we start stocking up on NMN?
Based on the studies, NR is as good or better so no need to stock up on NMN.
Also, you can always order from the UK at DoNotAge.com.
I just have to deplete my stock.
A good study of NMN effects on overweight individuals.
And a counterargument from Dr. Brad.
Seems the evidence is leaning towards NMN as not being worth it.
Thank you so much for sharing your particular NMN trial, this info is very helpful, desertshores.