The best known spin trap is PBN (Phenyl t-Butylnitrone), also called “Nitrone”.
According to Sawant,2 there are five primary spin traps of interest for health and skin conditions, based on safety considerations. These include: two nitrones, i.e., the aforementioned phenyl-N-tert butyl nitrone and 5,5-dimethyl-1-pyrroline N-oxide; plus, four nitroxides; and a hydroxylamine-TEMPO. To reduce inflammation in chronic diseases, 5,5-dimethyl-1-pyrroline N-oxide (DMPO) shows promise as the foundation for future anti-inflammatory drugs.3, 4 And phenyl-N-tert butyl nitrone appears to protect the central nervous system; especially the brain, which is very susceptible to oxidative damage.5
On a fundamental level, spin traps are like next-gen antioxidants. They make a proactive strike against free radicals by disarming and stabilizing them before they can cause damage. Antioxidants, on the other hand, while effective, are more reactive in nature, responding after the attack.