Risks and Benefits of Nicitinic Acid (NA), a NAD+ Booster
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Now a followup video from Dr. Greger about nicotinamide - sounds like megadosing is to be avoided.
Risks and Benefits of Nicotinamide (NAM), a NAD+ Booster
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Thank you.
But: the dosage of niacinamide to inhibit SIRT1 for an adult man is estimated at around 4000 mg, based on achieving a plasma concentration of 0.5 mM, as used in cell culture studies.
In the same time: niacinamide offers significant benefits for skin health (perfect for managing any kind of eczema - both topically and as supplement), skin cancer prevention in high-risk individuals, osteoarthritis management, and phosphorus reduction in CKD dialysis patients.
→ pulsed intake of 100-500mg daily make perfect sense for „some“ individuals :))
The series continues. NR doesn’t sound especially good.
Risks and Benefits of Nicotinamide Riboside (NR), a NAD+ Booster
Here’s one where he mentions its effects on glaucoma:
He mentions this paper:
Results: PhNR Vmax improved beyond 95% coefficient of repeatability in 23% of participants following nicotinamide vs 9% on placebo. Overall, Vmax improved by 14.8% [95% CI: 2.8%, 26.9%], (P = .02) on nicotinamide and 5.2% [-4.2%, 14.6%], (P = .27) on placebo. Vmax ratio improved by 12.6% [5.0%, 20.2%], (P = .002) following nicotinamide, 3.6% [-3.4%, 10.5%], (P = .30) on placebo. A trend for improved visual field mean deviation was observed with 27% improving ≥1 dB on nicotinamide and fewer deteriorating (4%) compared to placebo (P = .02).
Conclusions: Nicotinamide supplementation can improve inner retinal function in glaucoma. Further studies underway to elucidate the effects of long-term nicotinamide supplementation.
However, Brad Stanfield has a new video out where it sounds like he thinks the health and anti-aging benefits of NMN, NR, and perhaps also niacinamide are all a big scam:
