@ConquerAging Exactly! I want to learn from the best and help contribute as much as I can. As a group we can help each other to make improvements, challenge our intellect and think about things in new ways.
Thanks for joining us.
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This is brilliant work, I donāt know why youāre the one figuring this all out, but good job. I have some questions popping into my head.
Iāve heard nobody knows the shelf life of NR or NMN. Also people have bought from some places then found out from lab tests that there was no NMN in their sample. Is it possible thatās why it didnāt work? Because , come on, NR or NMN should work better right?
I donāt know where I read it now, but I think it was on this site. If you take Niacin with D Ribose it makes NR in your gut? If thatās true you could do it for pennies, mix the powders and it wouldnāt even taste bad. D Ribose is much better at glycating proteins than regular sugar, but you donāt need much. It tastes kind of like sugar plus metal.
Your book was amazing, Iāve read it like 5 times. Thanks,
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Minute 6:44 - lowest all cause mortality is at 140 mg LDL.
The BHF (British Heart Foundation) vehemently disagrees, calling the Ravnskov study flawed.
Typical of any discussion regarding cholesterol and statins.
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Perhaps mentioned in one of the articles above, but is there a difference between niacinamide and niacin here?
Niacin is one of the few substances I have a STRONG reaction to (usually I feel nothing from most substances even at high doses). A fraction of a typical dose puts me into agony for hours.
Yes, totally agree, talking about LDL and statins is never very productive. I checked some studies on lipid profiles of centenarians a while ago, from Japan, China, Europeā¦ and indeed their lipid profiles were not āidealā in any case. LDL for sure was not below 70. I believe there were also important changes in lipid profile that happen late in life in people that live longest, but I forgot which lipids rise and which decreaseā¦
What we will never know is if those centenarians with high LDL could be living an extra 10-20 years if they had lower LDL.
The same is equally true the other way around, ie the centenarians with LDL maybe they could be living longer if they boosted it.
Your above statement is based on?
Itās a perfectly valid supposition. There is no RCT.
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Itās not based on anything because itās just a possibility and we will never know either way.
Point is, arguing over what is the right level for LDL-c for any age is just a waste of time.
(And thatās the last thing Iām saying on this subject).
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Thanks John. Unfortunately that may be true, as weāll see in my next epigenetic-focused video
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I look forward to your video. I think the evidence is clear that a small slowdown in deacetylation is good for gene expression. NAD is likely to have an optimal range. However, increasing the activity of the sirtuins is probably pro aging. Hence if NAD levels are so high as to push up SIRT activity that is likely to be bad news.
Personally i am thinking of pulling back on NAD boosting. I dont detect a positive from it. I may therefore be in the overboosted space. Ideally i Need to find a good testing mechanism in the UK.
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I do not see how this can be backed by science tbh.
I think he should just use niacin like once a week, and daily supplement with TMG which is the most powerful methyl donor, much more effective than choline, and act directly even on adenosylhomocysteine
I am not sure which āthisā you are referring to. I am quite happy to explain the argument that histone acetylation affects gene expression. Its not really new science.
I have not tried to find the first paper about acetylation of histones, but there is this one from 1964
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FWIW: Why Novos doesnāt use TMG
"FAQ Ingredients & Other Supplements Why does NOVOS use glycine instead of trimethylglycine (TMG) or betaine?
Trimethylglycine (TMG), also called betaine, is a substance that is sometimes recommended for health or longevity purposes, mainly to improve methylation (which is the process of adding small molecules called methyl groups to the DNA to regulate gene expression).
TMG was one of the many substances we looked into when formulating our foundational anti-aging product NOVOS Core.
However, we refrained from adding trimethylglycine to our formulation for several reasons. For example, in some patients TMG can cause side-effects, especially in the long term, such as disturbed sleep or gastro-intestinal issues.
Also, in the context of methylation (which is very important), TMG is a more downstream molecule in methylation pathways. We therefore recommend to take more upstream methylators, like choline and/or phosphatidylcholine (that way, the body can choose itself how much methylation donors it wants to create), and a B vitamin complex.
We explain more about choline and phosphatidylcholine on this page: https://novoslabs.com/best-food-supplements-to-take-even-when-you-eat-healthy/ (see section 9 about choline).
We added glycine not specifically as a methyl donor but because other reasons, for example glycine can help to protect the epigenome, especially in mitochondria, and has anti-inflammatory and various positive metabolic effects and extends lifespan in different species. We wrote more about glycine and longevity here:"
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I have just refound this paper which goes into the gene transcription issue in more detail
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