According to Richard A Miller (NIA ITP), 16 alpha-hydroxyestradiol extended male mice lifespan the same as 17 alpha estradiol (15-18%) and shortened female mice lifespan by 3%
Not published yet from what I know
It seems like female hormones (estrogens) may be good for males and bad for females - exactly opposite what many people (and doctors) say
I don’t remember the exact video - it was a video with Richard A Miller on youtube or some podcast - he said it had similar effect to 17 alpha estradiol on males and shortened lifespan of female mice, but results are not published yet
Insight into what Rich though was going on with 17⍺-estradiol, and how badly they were wrong
Mike Garratt collaborated with a guy named Mo Jain to look at steroids in the tissues of mice treated with 17⍺-estradiol (among other things), and he noticed something really interesting
He found two steroids that were members of the estriol family (not estradiol) that were elevated at least 20-fold in males that got the drug
[reported as estriol‐3‐sulfate and 16‐oxoestradiol 3‐sulfate, metabolized from 17⍺-estradiol]
And they were not elevated in females at all
It was a male-specific production of estriol when 17⍺-estradiol was given, and we knew it was sex specific because if he castrated the males before the drug, you didn’t see the estriol production
The conversion from estradiol to estriol depended upon testosterone or some other testicular hormone
So Rich thought estriol was going to be the one that is going to work in both males and females
The dataset is 90% complete, and we’ll probably start writing it up in a month or two when we have 90% of the mice dead, but we had 50% of the mice dead
We’ve presented at meetings, and the data says that that guess was partially right and partially wrong
The hydroxy version of estriol is great for males
It’s actually at least as good as 17⍺-estradiol
We won’t know until we have the last few deaths, but it’s terrific
That was a good guess: you don’t need 17⍺-estradiol because the estriol works terrific
However, we thought it would work in females, and it is the first drug we’ve found that diminishes lifespan in females
So the idea that it would work to benefit females was wrong
Thanks for sharing that interview with Rich Miller. Was the reason why pure estriol was not used ever discovered? It would be very helpful to know if there were any serious issues with it. Any additional info on this would be greatly appreciated.
Does anyone have a good summary on the known and unknown differences between Estriol and 17 alpha estradiol in aging? I wonder why Bryan Johnson chose to use one over the other.
