Rapamycin Study (June 23): Treating 24-mth-old mice with rapamycin for 12 weeks extended their lifespan compared to controls w dose:1.5 mg/kg/week
Findings (longer survival, lower inflammation markers, elevated expression of Klotho protein, benefit to heart muscle cells, autophagy):
Survival: All rapamycin-treated mice survived, while 43% of control mice died.
Weight: Rapamycin-treated mice had minor but significant weight loss.
Inflammatory markers: Non-significant trends towards decreased levels of inflammatory markers were observed.
Autophagy: Rapamycin-treated mice showed significantly enhanced autophagy, especially in the kidney.
Klotho protein: Rapamycin-treated mice had elevated expression of Klotho protein, a biomarker of aging.
Cardiomyocyte function: Rapamycin increased Ca2+ sensitivity and force re-development rate in heart muscle cells. Szőke K - Search Results - PubMed
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A direct link to the abstract and papers (Open access)
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