New Paper: mTOR Signaling: New Insights into Cancer, Cardiovascular Diseases, Diabetes and Aging

The mechanistic/mammalian target of rapamycin (mTOR), a member of the phosphoinositide 3-kinase (PI3K) related kinase family, integrates intracellular and environmental cues that coordinate a diverse set of cellular/tissue functions, such as cell growth, proliferation, metabolism, autophagy, apoptosis, longevity, protein/lipid/nucleotide synthesis, and tissue regeneration and repair [1]. Although mTOR signaling is essential for proper cellular homeostasis, the aberrant activation of mTOR is potentially associated with a myriad of pathological outcomes, including different types of cancer, metabolic/cardiovascular/pulmonary diseases, and neurodegenerative disorders [2]. Considering the pathophysiological importance of mTOR signaling, we collected review articles, original research articles, and short communications in this Special Issue to advance our in-depth understanding of the mTOR-signaling network in different diseases for the development of novel mTOR-targeted therapeutic approaches.

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what is the conclusion? overactive mTOR is not good?

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