The mTOR inhibitor rapamycin is the most robust and reproducible pharmacological intervention to increase lifespan and healthspan metrics in laboratory animals. Several groups have independently shown that short-term treatment with rapamycin during middle-age in mice can prevent age-related decline or rejuvenate functional measures of health in various organs and tissues including brain, heart, kidney, muscle, oral cavity, immune system, and ovary. Here I will summarize the preclinical evidence that rapamycin can positively modulate biological aging and describe current efforts to determine whether these effects are shared in companion dogs and people.
I just asked and they say that they will make it available on the Internet. I’ll see if I can get them to email me the link when it becomes available.
Just some interesting tidbits that I noted from Matt’s discussion:
Matt Kaeberlein mentioned there is unpublished data that shows that everolimus increased lifespan in mice (not sure what lab or who did it).
Rapamycin is an anti-fungal, not an antibiotic (an important distinction to make - e.g. for people thinking it kills the microbiome, etc.).
There is interesting unpublished data that antibiotics have a positive effect on the longevity phenotype… not much published.
Matt - thinks the dog studies are better than marmosets for rapamycin studies. Dogs - genetically diverse, they live in the human environment (not a pathogen-free lab environment).
Marmosets closer in evolutionary terms, but many lab animals are heavily inbred, so don’t represent the human population well.
Might be easier to get it than rapamycin for Europeans, who don’t want to pay standard rapamune prices. Higher mg dose per tablet means less tablets overall per shipment.
I actually had a chance to chat with Matt K.
some before the program… he was surprised I asked if he was 53 or 54 years… he said 52 years… biological years…hopefully a lot younger. Lol.
Thanks for the heads up on this opportunity RapAdmin.
Just heard back from the organizers of the Kaeberlein zoom conference call. The video of the event will be posted here in the next week or so: (if someone sees it when it goes up, please post here).
