So, I have to wonder the effect of this drug is on healthy people…
About half of the trial’s participants were given the experimental drug, and the other half took a placebo and served as the study’s control group. Scientists measured the participants’ oxygen levels while they used treadmills or bicycles. Those who took aficamten had a significant increase in their maximum oxygen use—1.7 milliliters per kilogram per minute more than those in the control group.
I would think, by the mechanism of action, that it would not help healthy people?
Anyone else have opinions on this…potential applicability in healthy people?
Aficamten is an oral selective cardiac myosin inhibitor that reduces left ventricular outflow tract gradients by mitigating cardiac hypercontractility.
Paper summary here: https://www.nejm.org/doi/10.1056/NEJMoa2401424
More information: Martin S. Maron et al, Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy, New England Journal of Medicine (2024). DOI: 10.1056/NEJMoa2401424