New DNA mutations and Aging paper

#1

This twitter thread gives some figures from the paper which is behind a paywall

This is the paper:

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(23)00072-2#%20

This shows how rare mutations are in DNA given the number of base pairs:
“Germline mutation rate:
~1 × 10-8 per base pair per generation.
Somatic mutation rate:
0.3 × 10-6 to 3 × 10-6 per base pair
(10 to 100x the germline rate)”

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#2

I have been thinking about this and one thought is that germline cells are generally quite quiescent so it is not surprising if their DNA has fewer mutations in it. I don’t think it is necessarily a better repair system.