@medaura Thanks for all the useful information. I knew a good one wouldn’t be cheap. I’ll do some more research and try to determine if I can get the same results with isometrics. I’ve got a bum shoulder so I can’t do resistant exercises. Maybe I should think about an MRI and injections. Don’t want surgery. Have to credit all mothers and mothers-to-be for their bravery and tolerance for pain.
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Thank you but I can’t take much credit where 90% of it is due to this one little thing called an epidural 
Maybe look into RFP / exozome injections for the shoulder.
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@medaura, I just had had an epidural, which wasn’t bad at all.
I’ve never heard of Exozme Cyto-Tracers and other “stable lentivector systems, ideal for co-localization studies.” Are you in a medical profession? Are you British? NHS may pay for this but my insurance would balk.
@ageless64, @RapAdmin, et al. This paper looks more quantitative than the other version floating around. Good stuff for the number crunchers.
Correction: This is the same as the first one.
https://journals.physiology.org/doi/full/10.1152/japplphysiol.00698.2023
But the data behind this study can be found at
Especially interesting is the supplemental file Figure 1.docx, showing his best times, which, not surprisingly, increase with age. It also shows his times against the competition.
And here are some good pictures from a British rowing event, some of them showing nothing but pure exhaustion. At the end they have nothing left. I’ve been there and it’s painful, not from rowing but from climbing the Hancock. The fastest guys on our team could climb it in 12-13 minutes. But there was one guy, a freelancer, who would do it in 10 minutes, then take the elevator down and climb to the top again in almost the same time. Just a crazy level of fitness, like that of this ageless Irishman.
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Ahhh… thanks Tim-mer!
Wasn’t as hard as it might seem. Initially eat less… walk a lot… slowly build strength… low weights… add a bit more every few months.
Toughest part is committing to this as a new lifestyle.
Initially my shoulders had a lot of pain… now… nothing phases them… even on a hard work out… pull ups … no recovery… feel better… toned… tight.
And, now I can eat all day everyday. Muscle uses more calories… almost impossible to gain weight. Goes right back down
… maybe my weight setpoint adjusted by the rapamycin.
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Nope I’m in the U.S. Might even want to look into medical tourism for this as I know it can be offered for much less in certain countries.
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@medaura, I have an appointment Monday and I’ll see what he says. He’s mentioned PRP, stem cells, and Spinal Cord Stimulation, all of which seem premature to me. Plus, these methods seem to work for 50% of the people 50% of the time.
But one of the papers on PubMed offers this ringing endorsement of exosomal therapy: “the potential of exosomal therapy in the management of various neurodegenerative disorders, infectious diseases, musculoskeletal disorders, and cardiovascular disorders is overwhelming.”
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Well, there lies the answer. It is because he wasn’t active until later in life that he is in such a good shape now. It is on our DNA and it all makes sense. If you are not active until later in life and all of the sudden you start exercising, your body gets all the signals that this guy needs some help regardless of his age, because he has much to still accomplish for survival of the species. But if you exercise too heavily when young your body gets consumed and the messages that it gets is that this guy has already done what he had to do (for survival of the species) and it is now time to make him rest in peace. Rarely, you hear of a sports person living past 90. That’s why I always say that while young people should do moderate exercises, or better yet, very heavy but for short periods of time.
My intuition tells me something very much like that must somehow be at play but I have zero data to back it up or any proposed mechanism of action. Who knows if it’s specifically “the brain” that gets that message or if it’s all cellular signaling or joints getting worn out or whatnot. But my gut tells me the Attia model isn’t accurate. There’s a use it or lose it mechanism at play but also a use it now or use it later also at play so who knows what the best way is to maximize the interplay of those functions. Much more is known on the former than on the latter.
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You might want to look into pulsed electromagnetic therapy as well.
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I guess you are right - another way to say it is “use it or lose it”, but the thing is when and how much you use it is very relevant. I have a friend about my age that does a lot of running (late 50’s). He is in great shape, but he has all kinds of pains and problems. I have zero, none, and I am a bit on the fat side lol. I kept telling him that he is overdoing it but he wouldn’t listen, doing like 5-6 miles daily runs (to me that is border line crazy). Long story short his body is almost crumbling, and he complains about all kind of pains and joint problems. dah stupid, told him to do max 1.5miles but the last 300 yards to sprint. Lately, he has started to listen a bit (obviously he sees me healthier and stronger than a horse and have never run more that 500 yards at once, but usually that is all sprint).
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To some people physical activity is an addiction or such a key part of their lifestyle that even if they knew it harmed them long term they’d not give it up as it feels too good. At least that’s the case with the over exercisers like your friend sounds.
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That is actually very true and it exactly what he says. It has become such integral part of his daily thing that if he doesn’t do it for couple days, he feels miserable.
@medaura
I was a smoker into my 30s. Quit smoking and started martial arts at 35. Continued with the arts for 35 more years. Joined the fire department at age 48, becoming a runner and an avid stair climber. Very much against my wishes, I was forced out at 63 by mandatory retirement. Now 76, I will admit to aches and pains, but nothing that interferes with the sheer joy of running.
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Peter sent the following free article into my inbox today. I wouldn’t say he added much, but I am intrigued about the aspect of fitness as it relates to… "oxygen uptake kinetics (a measure of time required to adapt to a changing metabolic load) approximating those of a healthy man in his 30s or 40s. As I evolve into an older runner, I find it takes longer and longer to reach that uptake capacity. Something self-evident, but an interesting measure of older fitness.
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More discussions on this guy…
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Seems like a price hike has happened, I just checked the 5 handle unit and it’s C$2,273.38
At $400 I’d have purchased one 
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