I tend to be leucopenic even when not on rapa. My last result was 980 n vs 830 l. I think my protocol soups up short transcripts and i dont take any exogenous peptides.
I did 1.67 mg on three consecutive days. Can hardly get better results, but still ask do you think there is any advantage in spacing it more?
In clinical use, TA-1 is often dosed every day for months but that is for immune compromised individuals.
I’d do a more conservative approach like you are doing, 3 to 4 doses a week for 4 weeks and then test.
How long is the improvement expected to last? Can TA-1 be taken for a month every N months?
I also don’t gave an optimal NLR and do everything positive mentioned in this topic. ChatGPT suggested low-dose naltrexone, so I started 2mg/day 2 weeks ago. This is a good article about LDN for autoimmunity;
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My neutrophil-to-lymphocyte ratio went down:
2.62/1.43 = 1.832 (March 10)
2.68/2.17 = 1.235. (Apr 14). Now worry it’s too low.
It could be bc of medication change: replaced Labetalol by Nebivolol, changed to Rapamycin 1 mg/week. Positives: feel overall better, occasional face puffiness is completely gone, some skin spots became lighter, skin in general improved much. Negatives: very slight occasional headache, lower HR (49 daytime and 38 sleep).
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I’m going to throw some chit at the wall 
I’m going to use my engineering logic on this one. Which is probably different from a bio-science person with expertise in this area. So here goes…
- TA-1 is one of the 3 hormones the Thymus produces that maturate T-cells.
- The Thymus eventually stops producing all the hormones that maturate T-cells (Thymic involution)
- T-cells continue to be produced over our life span in an non-maturated condition
- T-cells produced during Thymic involution may not be properly or fully maturated?
- T-cells produced when Thymic involution is inevitably complete, are not maturated at all.
- There are 4 main groups of T-cells with variances within those groups
- Each T-cell type has different half-lives
My “if > then” statement
As Thymosin A1 is a key “maturator”
If - T-cells become maturated by exogenous use of TA-1
Then - the effect of exogenous TA-1 on any T-cell that gets maturated should last for the life of that T-cell as it does for those maturated during the functional life of the rapidly involuting Thymus.
How long do naive T cells live and how are they replenished? A short life span for naive T cells would necessitate faster rates of replenishment, whereas in- creased life span would accommodate slower rates of replenishment. Work in this issue of Immunity by den Braber et al. (2012) examines the longevity of naive T cells. Their data suggest that mechanisms maintaining T cells with naive phenotypes might differ in humans and mice
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And that is why I also use LL 37 when I’m working on my short term immune failures.
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Posted this a while ago, my understanding is you want to be close to 1?
N = Neutrophil (innate) L = lymphocytes (acquired and innate)
Rapamycin mainly affect Neutrophil (?) @DrFraser
As to NLR , my understanding per Gork is you want your L higher than R but the ratio between 0.78-3.5 is considered normal.
And FWIW, my own blood works has shown little change in lymphocytes over the course of rapamycin, but my neutrophil to some degree is a function of rapamycin dose (suppressed lower but still normal). Hence, I monitor the trend and ratio of my NLR as a way to gauge my rapamycin dosing.
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I agree - I think the major impact of Rapamycin is a decreased neutrophil count, and with that, you’ll improve ratio. I’ve seen some people have a little rise in lymphocytes, but not consistently. My average Rapamycin patient has a total WBC of around 3.5.
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AIUI because neutrophils have a short half life intermittent rapamycin hits them quickly
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