Our research results revealed that NecB substantially extended the lifespan of wild type Drosophila, showing an increase of up to 42.6% compared to the control group and 11.5% compared to Rapamycin (Rap). The extent of life extension achieved through this experimental study is the most effective achieved to date among other agents. We strongly believe that NecB urgently needs further attention and research, as we believe it has made a potential contribution to our understanding of the aging process as well as its application as a potential therapeutic agent for longevity and age-related.
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Wow! They need to add this one to the ITP list.
I’ll shake a little extra nutmeg in my keto pumpkin pie this Christmas. (It’s not really completely keto).
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A fascinating compound which I previously had not heard of.
I mostly found in vitro research, but still very interesting. Nrf2 activation, AMPK activation and enhances NO production.
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.31.1_supplement.1066.1
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Apparently nutmeg mace (the red seed shell) has the highest content (around 4-6%). I got this from ChatGPT, who lies sometimes. But I think this is accurate, going to add a cup of mace tea (already bought the mace) to my daily longevity rituals(s……) 
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" Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activatio"
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Patent
“Composition comprising extract of Myristica fragrans or lignan compounds isolated therefrom for treating or preventing vascular diseases”
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The posted link is:
“An interview with Sci-Hub Founder Alexandra Elbakyan Who exactly should pay for academic research”
Really? When I click on it I get the full paper:
Nectandrin B, a lignan isolated from nutmeg, inhibits liver X
receptor--induced hepatic lipogenesis through AMP-activated protein
kinase activation
Maybe you have to go to Sci Hub first?