NAD level doesn’t decrease with age

Human whole-blood NAD+ levels do not vary with age or lifestyle interventions

https://www.nature.com/articles/s42255-026-01537-5

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Would love to see the whole study. Some supplement companies will not like this, to me, this adds one more strike against NAD.

I would not say against NAD but i think the main issue is kyenurinine

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While I’m far from impressed by the clinical results of NAD+ precursors to date, I should play devil’s advocate for a moment: measuring whole-blood NAD+ levels is largely a wasted effort. To be honest, it’s rarely used in modern analysis anymore because it lacks clinical significance. Even your average biohacker has moved on to testing plasma NAD+ these days.

Our data show a significant decline in the plasma levels of NAD+, NADP+, and other important metabolites such as nicotinic acid adenine dinucleotide (NAAD) with age.

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Happy to DM the full study over to you. I haven’t actually gotten around to reading it, but I figured I’d keep it off the public feed to sidestep any copyright drama.

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That would nice, thanks. That will get me to also learn about plasma vs whole blood nad.