Biochemical Pharmacology
Volume 84, Issue 11, 1 December 2012, Pages 1522-1533
https://www.sciencedirect.com/science/article/abs/pii/S0006295212006417
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NACET is 10X more potent than NAC yet the dose is 1/10th that of NAC. So it seems like a wash to me except NACET is much more expensive.
I wish they studied NACET more because it has the potential to be far superior to NAC. Just wish the supplement manufacturers didn’t insist on including Molybdenum with it.
Yes it is, that is why I take/have been taken what I call “GlyNACET” the published paper protocol/dosing using NACET{600mg to 800mg per day] instead of NAC.
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I would think the required prerequisite assumption is that NAC is good for you?
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For the price, NAC still wins, or am i missing on something really important here?
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Sorry, I just read some of the older comments in the thread wondering why selenium and/or molybdenum was added to the NAC and NACET supplements.
I did wonder why my NAC supplement contains selenium. Apparently, there is a good reason to add selenium and/or molybdenum.
Edited shorter version from Gemini Pro:
"In short, NAC provides the raw sulfur material, selenium ensures you can actually use the resulting glutathione, and molybdenum ensures you can safely excrete the toxic sulfur byproducts.
The addition of molybdenum is primarily about metabolic safety and waste management. NAC and NACET are highly concentrated sulfur donors (cysteine is a sulfur-containing amino acid).
The inclusion of selenium and a reference table breaking down their roles:
| Nutrient | Target Enzyme | Primary Benefit in NAC/NACET Supplements |
|---|---|---|
| Selenium | Glutathione Peroxidase | Activates the newly produced glutathione so it can actively neutralize free radicals. |
| Molybdenum | Sulfite Oxidase | Safely clears out toxic sulfite waste generated by breaking down the heavy sulfur load |
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Yes I understand there is a rationale however I already consume plenty of selenium & molybdenum already so if I want to use higher amounts of NACET or Glycine that are on the label, I am forced to also have more selenium & molybdenum, which I would rather not overdose on. It would be nice if there was a version with only NACET or NACET & glycine.
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Where are you getting the selenium and molybdenum from? Your diet?
Perhaps I am getting too much myself. It is not contained in any other supplements that I use.
You can buy selenium-free NAC.
Both diet and multivitamin supplementation for selenium and just diet for molybdenum
NAC yes but not NAC-ET (as far as I’m aware)
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NAC does a lot of what NACET does but not everything. NACET is capable of more.
Even if treatment of posterior eye diseases causing irreversible blindness, such as AMD, diabetic retinopathy, or retinitis pigmentosa (RP), is urgent, these disorders are characterized by difficulty in their treatment due to the blood–retinal barrier, which strictly regulates drug permeation from the blood to the retina [16]. NAC and many natural antioxidants failed to obtain effective results in vivo due, in part, to their relatively poor bioavailability and pharmacokinetics [15]. In a preliminary phase I clinical trial, NAC modestly but significantly improved the suboptimally functioning macular cones in RP patients [22]. In that trial, to reach this goal, high NAC doses were administered to patients with the registration of gastrointestinal adverse events and a considerable variability in aqueous and plasma NAC, probably only because of its relatively low absorption and bioavailability [13]. Thus, another important observation of our study was the increase in GSH in the eyes of animals that orally received NACET, when NAC failed. Hence, the lipophilicity of NACET, and in general of ester derivatives of NAC, not only has the advantage of promoting their entry into cells and mitochondria, where they produce NAC and cysteine [13,21], but also of remarkably enhancing their tissue absorption and of crossing various blood barriers [13].
So far I’ve found this. I’m having a look around as I’m also curious to try NACET.
https://purerawz.co/product/n-acetyl-cysteine-ethyl-ester/
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