Sorry, was about to say exactly what I said previously (even though the message warned me) 
I tried the ITPP (5 gram bottle) from Umbrell Labs and noticed no effect whatsoever. I used 1 gram per week under the tongue. 500 mg the first day of the week, then 250 mg two days later and 250 mg two days after that for three weeks. The fourth week I double dosed and used 500 mg sublingual under the tongue four days in a row to see if a larger dose would be effective. Some days I jogged, other days I did a one hour non-stop swim and I did a 10-mile hike one day. With all of these somewhat higher intensity exercises I found none of them to be easier. It may be that injection is the only way that would work for me or it may be that the impact is too subtle for me to notice. I assume the product I received was ITPP? It had a bit of a salty taste which is a good sign, but who knows. I will suspend any further hope for ITPP being useful for me. If it were not so expensive I’d probably keep trying for a few months, but there are other things on my list and I gave this trial plenty of time. YMMV!
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I have been injecting 50mg ITPP with 50mg DMG 2x per week the night before recovery days. I was warned not to dose it more than 2x a week because overdoing it may reduce angiogenesis by reducing HIF-1α and VEGF signaling.
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GPT5 Deep Research summarizing all relevant studies off Pubmed. GPT is getting increasingly good at doing this.
Myo-inositol ITPP studies summary.pdf (59.5 KB)
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I wonder if just plain myo-inositol has some of the same effects, albeit much weaker. I actually take that supplement (and have thought of taking other inositol variants).
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I’ve been using Itpp on and off for years. I usually take 250mg sublingual about twice a week lately. It’s excellent before a long run.
People have been mentioning some very expensive sources… Itpp is available at pglchem, it’s the cheapest source I am familiar with.
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I hear it has quite a long half life. I might give this a go when I’ve got some extra cash. Currently running SR9009 I just got it. Hard to say but I think it is subtly benefiting me.
I did a big post on various exercise mimetics recently:
Curious if anyone with sleep apnea has tried ITPP?
Nice, I tried sr9011 years ago but didn’t notice anything noteworthy. Also Gw501516 but stopped because of the cancer discussion, I know people say they were overstated now.
Im aware of the discussion about slu-pp-332 not being very bioavailabile, however I notice a pretty strong benefit in my cardio when stacking 10mg sublingual, with the itpp. I can see a different in my running performance and corresponding heartrate being lower at a specific speed when I take them, so besides feeling like I have a few extra gears, there seems to be a measurable difference for me.
Yea I’ve noticed benefits from SLU-PP-332 as well. I just seem to lean out a bit more when I take it. I can’t take it late at night or I sweat a bit so I think it’s doing something.
Cardarine is annoying. I want it to be good lol. There are new PPAR agonists coming out so hopefully they are close without the risk, or new evidence comes out on cardarine clearing its name.
Kimerachem has a decent price for the injectable. I prefer to inject.
Better Through Biology is more expensive, also injectable
Kimera and everychem have powders
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SubQ or IM?
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IM to avoid lumps and pain just in general, but this is irrelevant for almost every compound. It’s only marginally relevant for testosterone in oils even.
The pharmacokinetics for ITPP are especially irrelevant because (1) it’s just dissolved in water, so it absorbs quickly regardless, (2) because of the lifetime of your red blood cells. Once it’s there, it’s there for a long while! So this is not a pre-workout injection like L-Carnitine, ATP, DADA, etc. I inject ITPP at night for convenience.
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Nobody is “letting” China make our drugs.
It’s called a free market economy, the source with the best price and quality wins the customer. If Canadian and US pharma’s can’t compete, they need to figure out how before they “onshore” under some ridiculous legislation to drive the price up.
Tariffs are a national security threat. They hurt the masses and cause dissent and poverty. Which leads to social unrest, which leads to…
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I’m for free and fair trade but if it’s to the point that we can’t start making our own stuff it becomes a national security issue. That was my only point.
I’m not an expert on tariffs, but it’s my understanding that others have had them against us for years. So that’s the fair part. And the deficit is also a national security threat. Politics is crazy complicated and crooked and really as peons we have no idea what’s going on. Your viewpoint is dependent on your source of news. I won’t argue further, you can have the last word if you wish.
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Most of the US companies are getting their raws from China anyway, and just reselling them at obscene prices. I stopped buying local stuff long ago when I realized this, and how much cheaper peptides and raws were directly from Chinese sources. There is an online telegram group of over 30,000 people who organize and independently test many vendors to keep them accountable and ensure it’s as safe as possible.
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Yes - most API (Active Pharmaceutical Ingredients) come from China. But the value-add that European and US companies provide is the quality control and reliability (backed up by a legal system that allows you to sue if you are harmed by the drug).
There is, unfortunately, an not insignificant risk that you take when you buy directly from Chinese suppliers… the supply chain is extremely opaque (half the time you can’t tell whether they supplier is the original manufacturer or one of the many tiers of middlemen) - and as a consumer or small company you are unlikely to do all the quality control for every batch that would be required by a commercial operation. And if anything goes wrong, you really have no recourse… good luck trying to get your money back or suing them for damages.
Maybe the testing done by the telegram group is good - but without knowing who the people are, what their expertise is, whether they are company sponsored “plants”, etc. … its really hard to judge, especially on a batch by batch, ongoing basis. There is, it seems to me, a fairly large leap of faith going on in this scenario. But of course, everyone has a different risk/reward profile.
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To be clear so we’re talking about the same thing, I’m referring to US companies that sell “not for human consumption” products, like Umbrella Labs or Kimera Chems. There is definitely no legal recourse if you complain to them you’ve taken their product and had a sever reaction or worse. They also generally are only doing some limited purity testing, like using Janoshik.
Im in Canada and was also thinking about single vial peptide vendors when I made my comment. With the exception of one producer who stopped selling to the public, most are just reselling from China, and all of them sell their products as not for human consumption.
Many risks are taken with limited recourse when exploring this territory, even ordering meds from India or just using drugs off label in an experimental way. I guess we all have to decide what our own comfort level is when seeking to further our health and longevity.
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