More on biological aging clocks and rapamycin, this time with marmosets. Horvath is primary author (2021). Marmosets are a big step up from mice.
DNA methylation age analysis of rapamycin in common marmosets
"In a separate cohort of marmosets, we tested whether intervention with rapamycin, a drug shown to extend lifespan in mice, would alter the epigenetic age of marmosets, as measured by the marmoset epigenetic clocks. These clocks did NOT detect significant effects of rapamycin on the epigenetic age of marmoset blood".
“The expectation that rapamycin would impede ageing is predicated on the assumption that ageing and longevity are inextricably linked. Although this assumption is understandably intuitive, it remains to be proven”
So this is Horvath on rapamycin and intrinsic aging.
So does rapamycin exert it’s effect INDEPENDENT of aging pathways?
As you know, rapamycin works by delaying age-related diseases such as cancer and very possibly CVD and AD. Since we die of diseases, not aging per se, this delay could add significant years to our life especially if we start young enough and hit the right dose.
Imagine coupling it also with early detection methods like CAC, colonoscopy, Prenuvo, and mammograms.
And then we may get additive effects with various supplements that we also take.
This will also allow us to live long enough for the next anti aging interventions.
That’s an interesting topic. How long would those on this site like to live assuming good health?
I think the 120-150 range . When I hit 119, I’m sure then that I’ll vote for 150.
Based on the raw ITP data no intervention has actually increased maximum lifespan. By that I mean the longest lived individual mice are female controls at ~1450 days.
However, by pushing the median and 90th percentile closer to the absolute maximum (122) more of us should live beyond 100.
I am hoping for a better health-span… and maybe an extra 2-3 years lifespan from Rapam. I think its very likely that there will be therapeutics/preventions that’ll be orders of magnitude better in the coming decades… but I just want to make it there first.
My guess is that most people wouldn’t be satisfied with an extra 2-3 years after taking a drug weekly for maybe decades. You can get more than that via behavioral modifications.
I am not expecting my shell to last that long…my longevity is defined by “brainspan”, my default definition of “living”. So if my brain function can be maintained, then I’ll take as long as possible, with at least 100 minimum with physical/brain combined.
By 2-3 years, I mean 2-3 years beyond what you’d get from behavioral modifications. And similarly with healthspan. But you may be right that some wouldn’t bother with it if that was the only extension they would get. But this is all so extremely speculative.