mTORC1 takes control of lysosomal lipid breakdown
mTORC1 integrates environmental signals to promote anabolism and repress catabolism. In this issue of Nature Metabolism , Hosios et al. identify a role for mTORC1 in controlling endosomal trafficking and degradation of membrane phospholipids in the lysosome, revealing a novel process used by cells to adapt to poor growth conditions.