Mount Sinai XPRIZE 2025 Healthspan Clinical Trial

#1

@DrFraser - just saw this.

Mount Sinai invites Principal Investigators to participate in the upcoming XPRIZE Healthspan 2025 clinical trial, a landmark initiative to quantify and optimize biological aging through immune, muscle, and cognitive outcomes.

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Objective

To characterize the immunodynamic effects of widely used longevity interventions, including Spermidine, Rapamycin, Metformin, and GLP-1 agonists.

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The study will generate real-world evidence on how these interventions modulate aging trajectories, while accelerating the transition from anecdote to evidence in longevity medicine.

Primary Outcomes

Validated Healthspan Improvement defined by personalized response thresholds across three key systems:

  • Muscle Function: endurance capacity (peak VO₂ ), lower body power, muscle mass (D₃-creatine dilution )
  • Cognitive Function : executive function, processing speed, working memory
  • Immune Function: ex vivo naïve immune response to novel stimuli, immune cell composition (IMM-AGE signature )

5 Reasons to Become a Physician Investigator

  • Pioneer evidence-based longevity medicine to help establish the protocols that will define the field
  • Offer your patients research-grade interventions with institutional backing
  • Build academic credibility through publications and contribute to the scientific foundation of longevity care
  • Get compensated for your participation: both PI fees and patient enrollment incentives provided
  • Minimal time commitment : academic partners handle IRB, biomarker analytics, and infrastructure

Physician with active patient panels apply now. Limited seats

APPLY TO BECOME AN INVESTIGATOR

Details:

https://www.mountsinai.org/about/newsroom/2025/mount-sinai-researchers-in-semifinals-of-101-million-xprize-healthspan-a-competition-seeking-innovative-approaches-to-aging-well

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#2

At least on the physician enrollment this looks like a recruitment tool into the group Longevity Docs - which is a reputable group. I suspect one would end up joining their group as part of this to get access to the protocols and testing - but I didn’t progress that far in the process.
I had talked with the lead physician at this group a few months ago, but didn’t see the need to join another certification beyond what I already have. It’s already a big challenge maintaining 5 items across 2 countries.

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#3

I’m really looking forward to the results of the XPRIZE. We need radical breakthroughs and I think it will provide some.