Evidence of Urolithin A as geroprotector in humans.
source: x.com
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Thank you for bringing the good news about Urolithin A. Iām ready to start taking it, and also, would a daily dose of 1000mg offer greater benefits?
Iām not sure thatās good news. Most trials are outside the inner circle so they are no significant changes.
In particular that shows again that there are mostly no significant clinical outcomes and only in-vitro ones.
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However, there is no double-blind study on whether weekly administration of rapamycin, coupled with the uncertainty of weekly administration, prolongs human lifespan or improves certain inflammatory markers.
Didnāt the Mannick study at least show an improvement in immune function?
Yes, one phase 2 study did, for ResTORbio, but then the FDA changed the endpoints for the phase 3 trial and that trial the drug failed.
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Chris Masterjohn gives a convincing reason why we shouldnāt waste our money on Urolithin A. You have to have a twitter profile to see the entire thread.
Since four months of Mitopure costs $500, itās worth taking a closer look at this claim. https://t.co/qX94D5emBlā / X
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There are several brands of urolithin A in addition to Timeline. Any experience with the less expensive brands?
Iām taking the capsules from get healthspan. Itās still expensive but definitely better than timeline, and I feel I can trust their quality.
Having said that, Iād love to find an even less expensive trustworthy option.
It was just last week someone here said they are sourcing it from Aeternum Urolithin A (UA) Powder ā The Aeternum Company
They do 3rd party testing, so maybe this is a good source, too?
My only worry, for me, is that itās a powder and I tend to be a baby about the taste of things.
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I have seen urolithin A brands that are liposomal. What do you think about that?
I am curious about liposomal supplements as well, but I donāt know enough about the topic. My number one would be if itās a trustworthy brand and if the ingredient inside is actually UA. Itās the only reason Iām paying more at the moment, because I donāt know who to trust.
I did just buy two different supplements from Renue By Science in thinking that my gut is potentially not very good, so perhaps getting something that supposedly absorbs better was worth a shot. I hope others who are better informed chime in!
Edit: @Bruce4654 btw, I got 3 months worth at 20%, which makes them 54.66 per month. Also, I just noticed the brand that sells the powders also sells capsules with no fillers. I see each pill contains 500mg, so if this is a quality brand (I donāt know), their capsules become very affordable.
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I have to admit that I take a lot of supplements and I donāt discriminate about various brands. I try to take liposomal versions for things like urolithin A and co-q 10. But I will look into Healthspan supplements. Thank you.
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Addendum:
But I will say that my mainstay is a high-polyphenol, whole-plant food diet, including various mushrooms, seaweed, nuts and seeds, whole grains, beans and legumes, herbs and spices in addition to fruit and vegetables, including lots of cruciferous.
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I eat similarly, but not nearly enough mushrooms and seaweed.
Iām less worried about brands for things we can measure for things like, letās say, vitamin dā¦ if there is no vit d in there, my labs will show it. I do follow the threads here on trustworthy brands and I try to mainly stick to those. Iāve seen the videos where they send things off for testing and there is zero active ingredients in the capsules.
After your post, I did some more searching and saw a couple of positive comments about the Aeternum brand, so I have asked my super brilliant friend if he thinks they are legitā¦ if so, Iāll switch. Iām all about saving money when all else is equal! If you do get healthspan, definitely try to wait for one of their 20% off sales.
On liposomalā¦
I took a test and found out I was deficient in coq10ā¦ and because ubiquinol is supposedly more readily absorbed, I chose that. However, I did see a liposomal coq10 option and wondered if that made it equivalent to ubiquinol. Because you are taking liposomal coq10, I would love your thoughts, if you have any.
I have to admit I am confused. But itās not your fault. I just never gave much consideration to brands. I get the least expensive versions on Amazon or Vitacost brand. The co-q10 I take is Besibest brand. Itās liposomal 1000 mg of ubiquinol. I take for two days and take off one day. If I had to research every supplement brand I would go crazy. But you made me aware that I should do more research.
I do take a lot of plant powders that I mix together to make my own anti-oxidant and high-polyphenol drink. I know you said you are turned off to bad taste. But when I drink it, the bad taste lasts only a few seconds. So this homemade drink consists of spirulina, olive leaf, beets (not SuperBeets), avocado, kelp, macha green tea, black tea, Life Extension coffee, various mushroom powders, etc. Many can be purchased from Nuts.com which has more than just candy and nuts, or from Amazon.
I know I am lazy when it comes to researching the quality and reliability of supplements.
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As an aside, did you know you can go to the Life Extension website and read their magazine as a pdf?
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Just yesterday someone I respect here told me they take an olive leaf supplementā¦ I had never heard of doing soā¦ so see, you are doing much better than you give yourself credit for!
Coq10 vs ubiquinol IS confusing. Iāve gone round and round on this before!
Coq10 is called ubiquinone
Ubiquinol Is a reduced form of Coq10 and considered more bioavailable.
I definitely think you can make it easy and buy inexpensive supplements, but at the same time, the universal message that I see is be very very wary of anything sold on amazon. I will buy supplements on amazon if itās from their āstoreā, but I no longer buy random brands from random places that I havenāt heard of.
To the best of my knowledge, vitacost is a quality company, but I have not heard about their house brand, but it might be good? iherb is also up there with vitacost and it was just within the past few days that people here were commenting that the iherb house brand is trusthworthy, so perhaps check them out.
NOW brand is universally loved and their prices are very good. That seems to be everyoneās go to. You mentioned life extension which is also seems to be a universally respected brand.
For powders people seem to like bulk supplements and pure bulk (but yeah, I have not bought the powders yet :)ā¦ on that note, and at your prompting, I might try it again. I now take a citrate powder mix, and mixing it in mango juice was recommended to meā¦ makes it much betterā¦ so as long as Iām throwing back a quick shot while holding my nose, maybe I should consider adding some more things to it.
I checked out your ubiquinol. So, I gather you were looking for a vegan brand (Iām vegan and finding vegan ubiquinol is limiting). Iām finishing up my expensive bottle, and afterwards, Iām switching to the Healthy Origins Vegan option (they have a non vegan option, so pay attention) Ubiquinol (Vegan) 100 mg ( Active form of CoQ10) ā Healthy Origins USA
I discovered them recently on a Ryker video (the anti aging YouTube channel) where he goes over the various brands and which ones are not dosed according to their label (he does lab testing and occasionally posts videos). People have pointed out he is biased due to being heavily sponsored by some brands, but I believe that even if he is slanted, he is not making up the lab results.
In another video, he showed Deva Coq10, not ubiquinol, had close to what the bottle says is in there.
Here is the video where he mentions healthy origins if you care to take a peak
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@Bruce4654
Here is the link to the thread from the other dayā¦ there are others as well.
PS California gold is the name of the iherb house brand, i think
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Yikes. Thatās a lot to take in.
Do you take omerga-3 and is it a vegan version?
I do take fish oil-derived omega-3, collagen peptides and a small amount of yogurt, so I am not completely vegan.
I do have supplements from Doublewood (lithium orotate and l-ergothioneine that is derived from mushrooms). Do you take nattokinase or fucoidan derived from seaweed?
Ha, well that was only a lot because my ADD dictates that Iām all over the place. Anyone else could have said all that in two sentences 
No reason for you to switch, but I take algae omegas
Iām currently alternating these two brands
When I want something that also contains DHA, I take
AstaMatrix that contains phospholipids. And they sell it on amazon
When Iām taking EPA only, I take IWI brand Heart version
(I got this on sale at Whole Foods)
I wish I could get over myself and take collagen, strictly for vanity sake, but thus far, Iām too ickād out by the thought (havenāt consumed meat since 1991). Iām taking Feel Vegan Collagen instead.
From anything Iāve heard, I believe algae oil is as good as fish, but I am skeptical if vegan ācollagenā does anythingā¦ just rolling the dice on that one.
Iām not taking nattokinase or fucoidan (hadnāt heard of fucodian). I see a lot of people do take nattokinase, but no one has told me I should, so I havenāt really looked into it.
I do have nori and I add that to my vegan caesar dressing and to spring rolls, but this is more of a 1-3x per month thing.
Iāve read that l-ergothioneine is great for us. I tired it once but didnāt rebuy it only to reduce what Iām taking. I do take tremella mushrooms from the real mushrooms brand because itās supposed to be great for our skinā¦ *see vanity above.
I make soy yogurt and love it (vegan or not, itās sooo easy to make any yogurt at home with an instant pot). However, I recently discovered oat milk yogurt from Icelandic which is my new guilty pleasure (12g of protein per serve). A little too much sat fat from coconut oil for my heart disease, thus āguilty pleasureā