Boost mitophagy via endurance exercise or urolithin A…and some other stuff. It’s a good read.
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Urolithin A is indeed highly worth taking. Recent studies increasingly show its excellent performance in mitophagy. The only downside is its cost.
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Hevolution Foundation and Dolby Family Ventures join Vandria’s 2nd Series A closing, bringing the total round to $30.7M (CHF 28.3M) to Progress the Mitophagy Inducer VNA-318 into CNS Clinical Development
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There are quite a few different mitiophagy inducers. An interesting question is how to tell the difference between them in terms of efficiency.
I personally think fasting serum levels of malate and citrate may give a good aggregate position on this.
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I was trying to be funny when I said endurance exercise OR Urolithin A. I thought the obvious conclusion was just use your body ….the body knows what to do. Maybe Urolithin A is a bridge but not a long term solution.
Another indicator of sufficient mitophagy might be general health status and ability to do longish or hardish physical exercise. That’s what I’m working on.
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Yes, an excellent article!
I would encourage people here to post a summary and/or the essential points/quotes when they post a link to an article, study or video. It’s extremely helpful now that there are more posts than anyone could keep up with.
Some quotes from the article:
" Here we will briefly discuss how exercise, nutrition, and pharmacological interventions can improve mitophagic regulation, improve mitochondrial quality control as we age, and prevent the accumulation of damaged mitochondria within cells & tissues."
"For the first time, he and the team showed that AMPK is actually localized to the mitochondrial membrane following exercise or energetic stress.Within this study, the team tested the hypothesis of metformin, a method of inducing energetic stress and thereby increasing mitophagy. Metformin directly impaired complex I, as previously reported, with little to no effect on mitochondrial respiration. However, as previously reported with exercise, metformin increased mitochondrial localized AMPK, indicating the potential for metformin to induce skeletal muscle mitophagy independent of exercise."
“To explore this further, the authors determine with a sensitive reporter model of mitophagy (termed ‘MitoKeima’ – A similar model to MitoQC). Following a 24hr exposure to Urolithin A in muscle cells, mitophagy was increased by ~104% compared to control. In mice, middle-aged adults, and older adults, Urolithin A has been observed to increase the gene & protein expression of proteins related to mitophagy.
Data from randomized control trials of middle-aged adults supplementing 1,000mg/day for 4 months reported improvements in muscle strength (~12%) and endurance performance (~12%). Muscle biopsies obtained pre & post-intervention from the vastus lateralis muscle of the quadriceps showed a significant increase in genes related to mitophagy, TCA cycle, and fatty acid oxidation, overall indicating improvements in mitochondrial health & function.”
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