Mitochonic Acid 5 - Mitochondrial ATP booster, NAD+ increase, SIRT1–7 activator, Hearing loss reversal. Group Buy

#1

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#2

What is the cost? How much are you getting?

#3

I will get at least 100 grams.

1 Like
#4

If the signature resembles that of OSKM or OSK induced pluripotent stem cells, might there be the danger of teratomas? I scanned the linked paper, maybe too quickly, but didn’t see anything that addressed it.

#5

I’d be interested in helping with a group buy.

#6

I would say no. MA-5 flips many of the same molecular switches and results in the same reversal of aged gene expression that OSKM does but does not have the same signal to induce pluripotent stem cells.

Using gene-set enrichment analysis (GSEA) against standard databases (KEGG, Hallmarks, Reactome), researchers compared MA-5–treated mice to both aging signatures and the OSKM iPSC signature . They found that MA-5:

Turns down the same ageing/stress pathways OSKM suppresses:

EMT, UV response, hypoxia, p53/apoptosis, TNF-α/NFκB inflammation, coagulation, complement activation.

Turns up the same youth-related pathways OSKM boosts:

Myc targets, DNA repair, E2F cell-cycle genes, ribosome/translation.

These patterns are positively correlated with the iPSC (rejuvenation) profile, and negatively correlated with age-related changes seen in mouse, rat, and human tissues.

#7

“I will be deep diving into all the papers on it this week.” Looking forward to your findings.

Probably because this was specific to hearing, estimated extension of lifespan wasn’t addressed. Maybe after phase 2 trials there’ll be some guesses.

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#8

I’m also interested what he finds.

#9

I am interested! Please share any pricing when you find a reliable source.

#10

I am getting the s isomer custom made and it will be available for about $50 a gram.

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#11

I would be happy to join Ryan if that is an option.

#12

What is the typical dosage? What about the stability and shelf life? (In a -20ºC freezer if that works)

#14

I think the optimal dosage is about 30mg for the s isomer. Not sure about shelf life. It should be soluble in MCT oil so that probably the best way to experiment with it.

#15

I would likely be interested in a group buy also. Depending on pricing of course. Thanks!

#16

I’m interested. But I live in France.

#17

Hi Ryan. I am interested in participating in a group buy. Even a benefit in my hearing alone may be worth it. Chris

#18

I am also interested.

#19

I am definitely interested! Let me know the cost if still available?

#20

I am interested in the group buy :slight_smile:

I’d be looking for 5gm if possible or more if you don’t have enough people joining in.

#21

I am interested in participating in the group buy. I would like to have 5g as well.