Thank you, @Walter_Brown: great news. It seems like an interesting (and relatively cheap) addition to hair and skin concoctions.
Yesterday I noticed that my lips were becoming fuller. I’ve also started Oxytocin SubQ. I’m also taking Epithalon (5mg per day for two weeks and intend to repeat twice a year).
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I just order GSK-Cu for a skin concoction which I am planning.
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Old thread but what’s your update on GSK-Cu a year later?
So much has happened to my longevity stack, but I still take the GHK-Cu. In fact I have made it a core part of my routine as it definitely rejuvenates me. I now take it intranasally with oxytocin (own mix) to get the brain benefits:
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Can you tell us more about what you do, how you do it, and what you get out of it — if you have any test results changing also?
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Sure.
- I buy lyophilized GHK-CU (25mg) and Oxytocin (2mg)
- With that order I buy sufficient bacteriostatic water to reconstitute the peptides.
- I reconstitute by adding the bacteriostatic water to the peptides.
- I then create two nasal spray bottles of peptide and bacteriostatic water solutions. I do this by equally splitting the solutions of GHK-CU and Oxytocin between the two nasal sprayers.
- I then fill the remainder of the 10ml nasal sprayer with additional bacteriostatic water.
- So in summary each nasal sprayer contains 12.5mg GHK-Cu and 1mg Oxytocin mixed in 10ml of bacteriostatic water.
- I then spray intranasally and inhale through my nose at the same time.
I haven’t had test results - but anecdotally both my physiotherapist and personal trainer independently noted improvements in my body control (recovering from MS relapse).
Given the nature of my neurological issues a more detailed and costly tracking of regular MRI scans in a controlled scientific study would be able to show objective changes.
Subjectively feel amazing.
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Cool! Where do you source it? I’d imagine you have to be very careful with the purity of anything delivered to the brain.
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I am very careful, but I wouldn’t recommend doing any of this stuff (NOT MEDICAL ADVICE). But, seeing as you ask, I personally - and they say it is only for research purposes, so they too are covered - use biotechpeptides (USA) or UK-Peptides. Both have 3rd party testing.
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How is it going? Stil doing the GHK-Cu intranasal?
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I am planning to start the Ghk-cu subcutaneous again as part of an OSK mimic protocol. Here is what I designed via ChatGPT. Standard health warning: I am not a doctor, this is not medical advice and LLM / AI can be wrong;
Goals
• Improve epigenetic fidelity
• Reduce age-related transcriptional noise
• Support chromatin maintenance and repair
• Enhance NAD⁺/sirtuin signalling
• Bias gene expression toward youthful patterns while preserving cell identity
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Core Stack (4 Pillars)
- Epigenetic Substrate Support
Supports DNA & histone methylation accuracy.
• Trimethylglycine (TMG): 1–2 g/day
• 5-MTHF: 400–800 mcg/day
• Methylcobalamin (B12): 500–1000 mcg/day
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- NAD⁺ / Sirtuin Axis
Supports chromatin regulation and DNA repair.
• NMN 500–1000 mg/day or NR 300–600 mg/day
• Apigenin 25–50 mg/day (CD38 inhibition)
• Magnesium (malate or threonate): 200–400 mg elemental/day
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- GHK-Cu (Repair & Gene Expression Normalisation)
Supports regenerative transcriptional programs (not epigenetic clock reset).
• GHK-Cu (conceptual systemic range): ~1–2 mg/day SC, cycled
• Typical cycle: 4–8 weeks ON → 4 weeks OFF
Mechanistic role:
↓ inflammatory & fibrotic genes
↑ repair, ECM, angiogenesis signalling
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- Chromatin & Inflammation Control
Reduces epigenetic “noise”.
• Sulforaphane: 20–40 mg/day
• Omega-3 (EPA+DHA): 2–3 g/day
• Low-dose lithium (orotate/aspartate): ~1 mg elemental/day
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Cycling Strategy (Example: 12 Weeks)
Weeks 1–4 – Reset Support
All pillars active; emphasis on NAD⁺ + methylation.
Weeks 5–8 – Repair & Consolidation
GHK-Cu ON; continue NAD⁺, methylation, anti-inflammatory support.
Weeks 9–12 – Stabilisation
GHK-Cu OFF; maintain NAD⁺, methylation, omega-3, sulforaphane.
This mirrors OSK’s intermittent expression logic to avoid loss of cell identity.
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Expected Outcomes
• Improved epigenetic stability
• Slower epigenetic aging trajectory
• More youthful transcriptional patterns
• Better tissue repair signalling
Limitations
• Does not replicate OSK-level epigenetic clock reversal
• No cell-identity reset
• Effects are gradual and cumulative
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Bottom line:
This represents a maximum-safe, non-genetic approximation of OSK-adjacent biology, focused on epigenome maintenance rather than reprogramming.
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