Mitochondrial origins of Parkinson's; oxidative stress. New ways out of PD before it takes hold?

#1

https://www.science.org/doi/full/10.1126/sciadv.adu0726

I was diagnosed ~2 years ago (I am 55 now) and started on rapa (8mg/8 days) shortly after the PD diagnosis. I’ve kept up with cardio (I ran 8 marathons through my 30s-40s and still ski and bike), added bodyweight strength training, and I also added CoQ10 and GLP-1 low-dosing in 2025 because why not.

This new R&D suggests none of this is a terrible idea. My ongoing approach is that I won’t know until my mid-60s, at minimum, whether I’ve bent the curve, so get busy living.

I’d be interested in any related reflections, helpful skepticism, or other advice. I mostly lurk here but it’s been excellent lurking. :^)

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#2

I think PD and ALS/MND are both initially a problem with mitochondrial collapse (the failure of mitophagy in some circumstances caused by a lack of melatonin).

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