Mito-fisetin, fisetin focused Mitochondria senolytics

I have been reading about a variant of fisetin molecule, specifically made to interact with mitochondria:

New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01664

It seems like a synthetic compound different from fisetin, did anyone has any take on this?

Fabio

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