Higher milk consumption was associated with higher relative abundance of Akkermansia
Akkermansia is a mucin-degrading, Gram-negative, obligate anaerobic bacterium [41] that has been associated with a healthier metabolic profile through improved glucose and lipid metabolism [42]. It has also been associated with enhanced gut barrier function, reduced age-related mucosal thinning, and decreased inflammation, contributing to improved colon health [43,44].
However, in fiber-deprived conditions, Akkermansia has been shown to promote colonic inflammation [45].
Furthermore, the supply of kefir exopolysaccharides was able to increase the abundance of Akkermansia (35). Akkermansia muciniphila undergoes changes according to the diet consumed, modulates the intestinal microbiota, changes inflammatory conditions in adipose tissue, and improves metabolic parameters, like body weight, adiposity, inflammation markers and biochemical parameters, which suggests a great potential for the treatment of obesity (74).
While natural yogurt consumers showed increased fecal levels of Akkermansia with respect to non-consumers, sweetened yogurt intake was associated to lower levels of Bacteroides . Serum levels of CRP were also significantly reduced in yogurt consumers. Our results underline the interest in exploring the potential effects of the different yogurt types and the role the microbiota may play in such effects.
Should be plain, not the (sugared) sweetened variety.
Lots of good information on the benefits and lots of promise.
For my part, I’ve paid attention to increasing Akkermansia, but haven’t noticed results.
Pendulum Akkermansia every day for over 4 months.
Supplement with prebiotic fiber (inulin and potato starch (resistant starch)) almost every day (for years).
Still no noticeable results.
I had my microbiome sequenced several years ago.
The following two measures illustrate dysbiosis (as a percentage of the entire sequenced microbiome):
Akkermansia 0.0120%
Firmicutes 90.6951%
I conjecture I came to this kind of imbalance by repeated (if necessary) uses of antibiotics since my late teens.
They saved my life in a couple of instances, but appear to have wrecked my microbiome.
I have had a worsening of autoimmune conditions every time I took antibiotics.
I have posted previously on things I did that helped, but it seems a constant battle.
I’ve submitted another sample for sequencing to see where things stand and should have results in the next couple of weeks.
Anyone have any thoughts on what I might have missed or things that can help?
I feed my gut with a pretty wide range of fiber and a lot of it.
I think my problem follows from the firmicutes dominating the microbiome.
Once they reach a certain level, competitors, loose their purchase of their environment.
I’ve reached out to schedule an appointment with Jose U. Scher, MD, Director, Microbiome Center for Rheumatology and Autoimmunity - MiCRA at NYU Langone.
