Microplastic accumulation in the brain, much higher in people with dementia, and 7-30 times greater than other organs

[trending topic on twitter, again]

The most common plastic found was polyethylene, used in plastic bags, food & drink packaging, and six times more in brain samples which had dementia

https://x.com/NTFabiano/status/1886476011669479639

BBB uptake

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I don’t understand why no one have found or sounded the alarm on plastic workers having so much plastic inhalation their lungs are filled with hem.

I mean, shouldn’t there be a signal with PE/PP flock workers with dementia etc? Or has no one looked?

From the Linkedin post above:

image

Paper was published in Nature, and if true, what the hell is going on there? Is it getting retracted?

Microplastics are too large to be handled by cellular mechanism, also I am not sure if they can actually enter the cells. Nanoplastics probably can and thus may be they can be sequestered or excreted.

https://x.com/RealAlexJones/status/1887183682655474114?s=19

The right wing has to freak out if we can ever convince this administration

I’m curious if those with APOE4 genes have more issues clearing out microplastic accumulation in the brain.

https://www.perplexity.ai/search/microplastic-levels-in-brain-r-_4ngpXDURoeRCCkUhOL4ww

Already covered today:

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What can be done about this contamination? Is there any way to purge it?

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And might rapamycin counter the resulting inflammation? What can we do?

I scored ~97%ile high for microplastics on PlasticTox’s microplastic test and have been doing infrared sauna daily, though not sure how effective it is. Maybe I will retest in a few months and see if there’s any impact.

Sulforaphane To The Rescue

Sulforaphane, a compound found in broccoli sprouts, is highly relevant for mitigating the effects of microplastic exposure. It activates the NRF2 pathway, which regulates detoxification enzymes like glutathione S-transferases (GSTs). These enzymes enhance the excretion of harmful chemicals associated with microplastics, such as BPA, BPS, and phthalates, by converting them into water-soluble forms for easier elimination via urine. Sulforaphane has also been shown to reduce oxidative stress and inflammation caused by microplastics through its antioxidant properties.
Animal studies suggest that sulforaphane can increase the excretion of toxins like benzene by up to 60%, indicating its potential for clearing microplastic-associated chemicals. Broccoli sprouts are particularly rich in sulforaphane, offering concentrations up to 100 times higher than mature broccoli.

Rapamycin

Rapamycin, an mTOR inhibitor known for its immunomodulatory and anti-inflammatory effects, has not been directly studied for microplastic detoxification. However, its ability to reduce inflammation and improve cellular resilience may indirectly mitigate some effects of microplastic exposure, such as oxidative stress and immune dysfunction. Studies on mice show that rapamycin enhances survival against pathogens by improving immune responses, suggesting its potential to counteract inflammation triggered by environmental toxins like microplastics.

https://www.perplexity.ai/search/scored-97-ile-high-for-micropl-0d1.4ew8R2u764kHVjWd8Q

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Does sulfurophane work for microplastics directly? Or just related chemicals?

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only “excretion of harmful chemicals associated with microplastics, such as BPA, BPS, and phthalates, by converting them into water-soluble forms for easier elimination via urine”

NOT the actual PE/PP/PS fragments that can jam blood vessels and autophagy machinery

Unfortunately ppl often confuse the MP-associated chemicals with actual MP fragments and it has distorted both research targets and advice.

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