Methods to prevent staph infection / rash?

I might have had a canker sore once due to rapamycin, but I’m noticing that skin issues that seem like staph infections have become more common when I take it.

What are the best ways to avoid getting a staph infection? Do any of you have a protocol for this?

I’d imagine that some additional attention to hygiene might help. A bit of googling suggests that tea tree oil, active manuka honey, and coconut oil all have anti-microbial activities. So I’m looking for a lotion which has these.

Any other ideas or suggestions here?


Actually, would finding a way to populate my skin with good bacteria be a better option? I’ve seen some products that I’d never thought much of till now.

And maybe anti-microbials may be best to use if I get an infection, rather than to prevent an infection?

I think the rash (at least that i get) is just contact dermatitis. I use cortisone /cortisol cream on it and it goes away.

Where and how large is your rash?

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IMO you shouldn’t just assume it’s a recurrent staph infection and go down that rabbit hole when it could very likely be something completely different. It’s very easy to get a skin swab culture (primary care or urgent care provider can do that) to rule out a staph infection.


@shc I recommend you read this thread about another rash a person had with rapamycin.

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I’ve had rashes before and I just let it recover on its own.

What I recently got a little concerned about are what I presumed were staph infections — these basically look like small bubbles that forms on my skin that can be very easily be popped — there’s no pus but there’s a transparent watery liquid underneath. These can vary in size from the diameter of a ball point pen nib to that of a highlighter.


I have added vitamin A, 10,000 units per day. This seems to have helped. BTW, I am not convinced that they are infectious.


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You’ll likely know a soft-tissue skin infection if you have one. Any staphylococcus infected lesion will usually form a golden crust w/o healing each morning (Doesn’t the word Staphylococcus have something to do with “a gold rim”- or maybe I am nuts (or know it) :slight_smile: ? My infections (have not had one in a while on Rapamycin but fielded a few in the past) usually start with one lesion (which may look a large papule but over the next few days, despite an exploits of a mass amounts of clear fluid but are just as inflamed the next morning and look just “off.” The infection can come on very subtle, one small uninflected blemish on the skin because so over the next few days- my spreading leaves small gaps in parts of my faces than groups of not normal sized pustules that appear almost in patches. Almost always, my infected lesions will burn just from the hot water so it’s obvious. A culture is always nice to all back on but typical treatment for suspected uncomplicated methicillin susceptible staph or strep- something like Cephalexin (Klex) and a topical anti starch/strep prescription ointment.
If it’s Staph or Strep, despite fears of MRSA now everywhere in our community, this combo will work 73-75% of time. Now, you may have MRSA, community-acquired, which is why you are glad you got an infected lesion cultured earlier :), something like Bactrim or Tetracycline as well as newer Rx anti-bacterial MRSA effective ointment. Once I had a Paeudomonas infection, a gram negative bacterium not nearly as common as Staph. In that situation 5 days of Oral Ciproflaxcin or Levoflaxcin (Cipro or Levaquin) will do it.

How to prevent? Great question. Huge fan of general hygiene :), think broad spectrum daily Probiotic, obviously not touching a lesion, no matter what. Use of double or triple antibiotic creams or ointments (OTC- Neo or Polysporin) when used if injury occurs, used until lesion as healed, shows a dramatic reduction in skin infections.


The infections I have gotten are very similar to the ones you report getting. Do you know what this is, if not staph?

Thanks for the heads up on cehpalexin, and tetracycline.

Probiotics shouldn’t touch the lesion even though they’re “good bacteria”? I thought this would mean they’re relatively harmless, and potentially help mitigate the spread of the “bad” ones

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I think Probiotics may in general just improve overall immune response and help balance the delicate millions upon millions of organisms that
reside on the human skin in balance. Certainly, different strains of probiotics have other properties but conventionally I do not think Probiotics work like Antibiotics. A good probiotic should help with preventative portion of even getting an infection but once infected, antibiotics are usually required.

The only reason I mentioned Tetracycline or
Bactrim are for skin infections which are highly suspected of being a MRSA strain, due to failed response of antibiotics already, past experience, or a culture. These 2 antibiotics are neither a 1st line skin ineffective, targeted for MRSA in particular.

If something like Keflex and Bactroban Ointment don’t cure it, usually a more serious infection or strain is the issue. Either you’ll need to graduate to MRSA covered Bactrim, Tetra, or Levaquin or you have a gram negative skin infection (Pseudomonas, E. Coli) - more rare but require Gram Negative covered antibiotics (Cipro, Levaquin, etc).

I highly recommend a culture at first suspecting of infection of the skin but if reoccurring (even just a 2nd time for sure). You can find out if you have a bacterial infection, fungal infection, etc. or no infection at all! Could be a bad rash requiring some corticosteroid cream or something other.

It’s good to know more info about these reoccurring issues so you may help prevent them, know what works, and to be careful on the Rapamycin.

My infections will start with one lesion. Usually after 3 days of not going the way I want, if it looks and feels odd at 44, it likely is. When the spreading starts it’s an easy read.

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Tea tree oil is some thing that I’ve used for years with great success. Probably the reason that I don’t get skin irritations even though I’m on a high dose 22 mg of Rapamycin every 15 days. What makes tea tree oil so good is that you can put it everywhere including the scalp and it will rejuvenate your skin also.