This is the first study to demonstrate that systemic interventions using Metformin in non-diabetic individuals aimed at PD prevention have oral-systemic effects constituting a possible novel form of preventive medicine for oral-systemic disease management.”
Given that rapamycin has also been shown to prevent/reverse periodontal disease in animal models by different mechanisms, it seems likely that the effects of rapamycin+metformin would be additive or synergistic in PD. This may be yet another example of how these two drugs work together in slowing aging.
metformin lowered glucose, reduced weight, and prevented periodontal disease in the mice. In the gum tissues, the data says there was lower IGF-1 and TNF-alpha.
Interesting. What is the role of saccharin or sucralose here? If it’s about sugar, then there’s xylitol which has good impact on the gum bacteria (don’t swallow!).
The topical vs systemic is quite interesting.
I have the following idea. My dental hygiene is exemplary according to both my dentist and periodontist. I am going to ask my dentist to do a very thorough workup of my oral health, pocket depth, extensive x-rays etc. and record it, as a kind of a baseline. Then, when I get on rapa, after I’ve been on it for a decent interval of a few months 6mg/week, I’ll ask the dentist to run all those tests again for a comparison. I will maintain my usual oral hygiene, diet etc. Hopefully it can be a somewhat objective way of seeing if there are any visible changes with the rapa addition. I can also perhaps experiment by later adding a topical routine as described with DIY rapa toothpaste to see if there is any impact, or if the systemic rapa intake is what matters.
