Metformin as a PSCK9 inhibitor?

#1

It’s good to stir things up sometimes, so being a little controversial, here’s one for the pot…. since I know how some people love metformin

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Metformin-induced PCSK9 inhibition further decreases LDL-C following statin treatment in non- diabetic patients with coronary artery disease and hyperlipoproteinemia(a)

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and here’s another paper, or two

Metformin enhances LDL-cholesterol uptake by suppressing the expression of the pro-protein convertase subtilisin/kexin type 9 (PCSK9) in liver cells - PubMed.

Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway | Scientific Reports.

There is a very interesting bit about statins in that last paper.

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