Thank you for this. This seems to explain more:
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I think the 500% increase and itâs effect on mitochondria align with the target of your citrate research (mitochondria)
The target of the citrate is really the nucleus and the transcription of DNA although quailty functioning of the mitochondria is important as well.
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@John_Hemming Iâm about to add Telmisartan to my longevity stack. I donât have high blood pressure but the longevity benefits and healthy ageing (muscle AMPK up regulation) are convincing. Iâll be tracking my BP for risk of hypotension.
But, on topic, POTASSIUM citrate is our for me.
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Yes, that will be NICE setting the protocol. The NHS has a strong tendency to caution. It is changing though. HRT, statins, glucose control should all be available easily
If you look at its composition in the paper I linked it seems to be salicin.
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Per ChatGPT
- White Willow Bark vs. Aspirin:
- Pain Relief: White willow bark has been shown to have strong pain-relieving effects, confirming its historical use as an analgesic.
- Equivalent Salicylic Acid Levels: A white willow bark extract with 240mg salicin (a normal dose) raised serum salicylic acid levels equivalent to 87mg of aspirin.
- Pathway Similarity: Normal doses of white willow should directly mimic the pathway by which aspirin increases hyperactivity from caffeine1.
from Reddit:
White Willow Bark: A Way Better Aspirin & Possible Nootropic
https://www.reddit.com/r/NooTopics/comments/uug3v5/white_willow_bark_a_way_better_aspirin_possible/
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what are the basis for this Telmisartan addition? Any studies that you can link?
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Telmisartan is a type of Angiotensin II blocker
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