MitoSwab. Very happy with their reports. Not only looks at your level of mitochondrial activity but also channel efficiency.
Chad Lerner is fun to talk to
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Interesting⊠launched this past summer, and sounds like its more for research than personal use:
VersĂ©a Discovery, Inc. Announces the Official Launch of mescreenâą Research Validator â a Revolutionary Mitochondrial Compound Assessment Platform
August 27, 2024 06:00 AM Eastern Daylight Time
TAMPA, Fla.âBUSINESS WIREâVersĂ©a Discovery, Inc., a Florida-based company dedicated to advancing scientific research and development in the area of personalized and precision medicine, has announced the official launch of mescreenâą Research Validator.
The mescreenâą Research Validator is a groundbreaking, proprietary compound assessment platform that harnesses mitochondrial function and dynamics to generate critical data, supporting the development, formulation, and clinical validation of customersâ supplements, nutraceuticals, pharmaceuticals, biologics, and medical devices.
By utilizing patented optimized bioassay, imaging, and machine-learning process, the mescreenâą Research Validator delivers valuable insights into mitochondrial efficiency and the clinical effects of various test materials in-vitro and in-vivo.
Research utilizing VersĂ©aâs proprietary machine learning system has analyzed over 60 FDA-approved compounds and probes known to impact mitochondrial function and dynamics. These studies have demonstrated the platformâs capability to detect changes in mitochondrial function and structure upon the introduction of test materials into the assay. The platform is also able to detect changes in mitochondrial function when therapeutics, interventions and lifestyle changes were introduced to and implemented by subjects.
âWe are thrilled to bring this groundbreaking technology to market,â said Stephen Porada, the President of VersĂ©a Discovery, Inc. âmescreenâą Research Validator has tremendous potential to help companies validate or optimize the performance of their bioactive molecules, ingredients or physical interventions being targeted for commercial product development.â
Dr. Hemal Patel, Chief Scientific Advisor of VersĂ©a Discovery, Inc., added, âIn addition to this important advancement, we are currently developing the mescreenâą Personalized Mitochondrial Efficiency Test, which aims to provide individuals with a comprehensive energetic profile. This test will utilize a 12-matrix panel to accurately quantify core functions and dynamics providing important data and information related to oneâs mitochondrial efficiency. Our commitment to enhancing mitochondrial health will empower individuals to better understand and improve their well-being.â
To gain insight into the science behind mescreen⹠Research Validator and explore how it can benefit your research and product development efforts, please contact Verséa Discovery, Inc. at discovery@versea.com or call 1-800-397-0670.
About Verséa Discovery, Inc.
Verséa Discovery, Inc., headquartered in Tampa, FL, is a U.S. company committed to advancing scientific research and development in personalized and precision medicine. Operating as a strategic business unit of Verséa Health, Inc., the company specializes in developing innovative solutions that deliver critical insights into health at the cellular and mitochondrial levels. To learn more visit Verséa Discovery webpage.
Disclaimer: mescreen⹠is for research use only and is not intended to diagnose, treat, or cure disease. You should not change medications, diet, exercise regimens, or other related health activities without consulting your physician. mescreen⹠has not been reviewed by the Food and Drug Administration. mescreen⹠is a trademark of Verséa Health, Inc.
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I checked this company months ago as they have (had?) a lactoferrin test that could be used for the early diagnosis of Parkinsonâs and/or Alzheimerâs. That test was very serious. I donât know about this new mitochondria test though.
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https://x.com/trikomes/status/1924906797200245138
The dashboard youâre looking at is not an organic-acids profile.
It comes from a direct enzyme-activity panel that the lab runs on the mitochondria-containing cells in your blood sample (mostly platelets and leukocytes). In each well of a micro-plate the lab:
- immuno-captures one respiratory-chain complex (or citrate-synthase as a reference),
- adds a very specific substrate/cofactor mix, and
- follows the initial reaction rate by watching a change in light absorbance.
What is being quantified in each well is therefore an enzyme-catalysed reaction rate, not a circulating metabolite.
Here are the actual reactions and the âreporterâ signals the spectroÂphotometer tracks:
| Report line | Enzyme reaction in the assay well | Spectral âreporterâ that is monitored |
|---|---|---|
| Complex I (NADH dehydrogenase) | NADH â NADâș + Hâș (electrons passed to ubiquinone analogue) | Disappearance of NADH at 340 nm |
| Complex II (Succinate dehydrogenase) | Succinate â fumarate (electrons to CoQ analogue) | Reduction of DCPIP or decyl-ubiquinone (600 nm) |
| Complex II + III (Succinate : cyt-c reductase) | Succinate â fumarate â cytochrome c (via complexes II & III) | Appearance of reduced cytochrome c at 550 nm |
| Complex IV (Cytochrome-c oxidase) | 4 Red-cyt-c + Oâ â 4 Ox-cyt-c + 2 HâO | Loss of reduced cytochrome c absorbance at 550 nm |
| Citrate-synthase (normalises for mito number) | Oxaloacetate + Acetyl-CoA â Citrate + CoA-SH | Formation of TNB from CoA-SH + DTNB at 412 nm |
So the only âanalytesâ the instrument is reading are:
- NADH (Complex I)
- DCPIP / ubiquinone analogue (Complex II)
- Reduced cytochrome c (Complex II + III and IV)
- TNB (Ellmanâs reagent product) for citrate-synthase
The green/orange gauges you see are simply each reaction rate normalised to citrate-synthase activity and then expressed as a percentage of a healthy-control mean. No plasma metabolites (lactate, succinate, organic acids, etc.) enter into these particular numbers.
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Is that another mitochondrial test?
Mhi
Thank you for this. I had a full genome test suggesting that I have some degree of Complex I deficiency as well as an OAT test showing something similar. Would be cool to see it confirmed again here because I am not a genetics expert and didnât know what I was doing with the whole genome data.
I wonât be trying this though because I think the price is unreasonable. The cost of the full genome test and the OAT test combined was still much less than this. Iâll keep my eye out for similar tests.
This is a test I heard of a while back: https://www.iollo.com/
Pricy, but still less than the Mescreen. Canât vouch for it other than I heard of it years ago and bookmarked it.