I’m curious to know if anyone has tried Melatonin 3mg nightly for its anti-aging effects. This seems to be a remarkable and under appreciated substance that has many wonderous effects on health. Besides ingesting it it has shown promise as a skin treatment and also for oral health.
Curious to know the experience of this very atuned group.
Kindly,
Martin
I used 3mg nightly for better sleep for about 2 months, but it’s like after a while your body gets used to it. Since 2 months I have been using 10mg with succes
What’s the evidence for this, especially at this specific dose?
I use 1.5 - 3 mg once or twice a week. Now I’m using time release tablets, but this is the first time, I used to use normal or oral liquid. I do this because I have getting off to sleep issues. My reasoning is that mel production declines with age.
I alternate with valerian tablets/tea. I find if you take M on successive days it soon loses effect. I don’t know if it has any anti-aging effect. I don’t believe I’ve seen any major research.
I take 720mg of melatonin daily. 480mg just before bed, and the remain in 4 60mg doses throughout the daily. I do this mainly for its anti-cancer and anti-viral effects.
I first became aware of this from the following presentation:
After watching that I started taking 180mg of melatonin a day. About 9 months later I saw this presentation:
I then upped my dose and I am currently taking 780mg of melatonin a day. I have been doing this for about a year now.
how do you feel? I plan to go high myself on melatonin
If you search this forum, you should locate:
Schallenberger notes and slides to the presentation posted
And a PDF copy of
Reiter, Professional Medical/Research book, Titled.
“Melatonin Biosynthesis, Physiological Effects, and Clinical Applications”
Reiter is the leading authority on the planet, he is the “Melatonin Master.”
I feel great. No side effects. I didn’t even titrate up, I just started taking the high dose.
According to Reiter, there is no maximum safe dose of melatonin. No amount of melatonin kills test animals (suffocation aside, I suppose). He says he take ~80mg per day at night, and adds more if he gets sick. Doris Loh advocates for much higher doses for COVID / Flu.
I’m trying to ramp up. I’m only at 10-20mg taken at night only, and usually only if I wake up around 1-3am, following @John_Hemming protocol on timing. I will take before bed if I’m not sleepy at my normal sleep time.
I am planning to experiment with taking during the day. At this point I don’t understand the impact of exercise adaptation so I’ve hesitated.
I looked up the Reiter book. It is dated 1993 and doesn’t seem to have been updated since then. The biochemistry may be first rate, but I am inclined to think that data and practice will have advanced since then.
I don’t know why 3mg was specifically mentioned as the dose in the original question, but I do believe melatonin is very important as we get older. I take 1mg sublingual, a little more than replacement level dosing (which is around 0.1-0.8mg). I’m still not completely sold on the massive dosages, but I reserve the right to change my mind at some point.
Its really hard to get any IP with melatonin so noone really wants to pony up any dosh.
Reiter has publish a ton of work on melatonin. As recently as last year I saw a new paper. He also runs a journal on melatonin.
I think 3 mg is mentioned as it is the most popular and available type of tablet. I usually cut mine in half as I find 1.5 mg is enough for sleep and it is around the replacement level.
I like to use sublingual since it seems to be more bioavailable. Natrol makes 1mg sublingual tablets so I like to take one before bed.
However, time released melatonin is only available in pills as far as I’m aware so I’m not sure which version would be better to take.
Again, I see no evidence for this. Wholesalers like Costco don’t even sell 3 mg, they typically sell 5-10 mg.
Melatonin is maybe helpful, I use it for sleep in formulation called Sleep #3 along with some herbs and l-theanine - seems to help.
I have seen dosing between 300 mcg to apparently 720 mg a day used ! That is over 2000 fold span. So unless there a DBPCS confirming some benefits at consistent dosing, I would refrain from making blanket statements regarding the dosing.
I vary my melatonin consumption each night because I am also using it to extend sleep as well as dosing to protect mtDNA from harm. These are my figures for the last couple of nights. (mg)
1840 1240 2080 1840 1200 1800 920 1660 1460 1160 1220 1160 1160 1120 1820
The largest pill I take is 60mg so I take a lot of pills.
I also use 60mg (liposomal gelcaps), What is your reasoning for varying your amounts?
I vary the amounts to maximise my sleep within the available sleeping time.