Lutein and atherosclerosis: Belfast versus Toulouse revisited
“At the time we speculated like others that role of the carotenoids may well have been to prevent oxidation of lipid in the lipoproteins and so reduce the uptake of oxidised lipid by macrophages and its deposition within the intimal layers of the major arteries as plaque. It is now widely accepted that CHD is an inflammatory disease and that macrophages within plaque together with tissue damage contribute to this inflammation. Stimulated macrophages release cytokines to activate the immune system both locally and systemically. Precursor complement proteins in the blood are activated to assist immune cells in phagocytosis and cell repair. Individuals with a history of arteriosclerosis display significantly higher concentrations of complement factors C3 and C3a than subjects without such a history. Metabolism of C3 via the alternate complement pathway can give rise to the membrane attack complex (MAC) which creates a hole or pore in pathogens or host cells, killing the cell. Recent studies in patients with early age related macular disease (AMD) who also exhibit similar elevated concentrations of complement proteins in their blood, showed supplementation with lutein progressively decreased the amount of the MAC and other complement factors in the blood. Lutein was used in the supplementation experiments because it is an important constituent of macular pigment. Thus the healthier cardiometabolic features displayed by the people in Toulouse may have been due to the effects of concurrent high concentrations of plasma lutein on the immune system and complement in particular.”
Lycopene in the Prevention of Cardiovascular Diseases
“It is believed that the cardioprotective effect of lycopene protection is a result of its potential antioxidant properties responsible, inter alia, for: protection against oxidative stress-induced myocardial hypertrophy by improving ROS production [44], inhibition of stress-induced endoplasmic reticulum damage due to ischemia/reperfusion (I/R) [45], inhibition of LDL oxidative damage [46]; suppression of ventricular remodeling after myocardial infarction by inhibiting apoptosis [47], and improving endothelial function [48].”
Antioxidant and anti-inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review)
" The LDL oxidation time in the presence of astaxanthin has been analyzed in vitro and ex vivo . In the in vitro assays, astaxanthin prolonged LDL oxidation in a dose-dependent manner, in addition to being more effective compared with lutein and α-tocopherol. In turn, the blood samples of individuals who were supplemented daily with 1.8, 3.6, 14.4, or 21.6 mg astaxanthin for 14 days evidenced a significant delay in LDL oxidation when compared to samples collected before supplementation, the greatest effect being obtained with the dose of 14.4 mg (oxidation time increased by 5.0, 26.2, 42.3 and 30.7% with 1.8, 3.6, 14.4 and 21.6 mg astaxanthin, respectively) (Table I) (10). Thus, it was demonstrated that the intake of astaxanthin delayed LDL oxidation, one of the key factors involved in the process of atherosclerosis."
Lutein, zeaxanthin, and meso-zeaxanthin supplementation attenuates inflammatory cytokines and markers of oxidative cardiovascular processes in humans
“Our data show that L, Z, & MZ supplementation results in decreased serum IL-1β, TNF-α, and OxLDL. This suggests that these carotenoids are acting systemically to attenuate oxidative lipid products and inflammation, thus reducing their contribution to atherosclerotic plaque formation.”