Review the following, this would apply to many if not all blood products.
It’s a great idea! Maybe storing plasma is easier than storing blood for a long time?
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Educational read;
Review
“Guidelines for Intravenous Albumin Administration”
20170315-guidelines-for-intravenous-albumin-administration.pdf (278.9 KB)
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With all due respect, it’s difficult for people with serious illnesses to get PLEX… insurance won’t even approve it for many neurological and immune/autoimmune diseases.
As someone with a serious chronic illness who has been trying to get PLEX for years (have done Rituxan and exosomes as well as other MABs, pre-Rapamycin), I would put forth that it should be reserved for those who need it most, as it’s not widely available. If that changes in the future, great! The costs could come down for everyone…
Also, I’ve heard from other patients that it’s not the easiest treatment, but everyone is different.
We are not speaking about insurance paying for this.
We are speaking about off label, longevity use, expermential use, pay out of pocket/self pay.
Such as biohack this as a do it your self.
The easiest way/least expenssive way;
Remove 1 unit{500ml is a unit of blood] of whole blood.{this would also reduce your iron level, a side benefit]
Then infuse 500ml of 5% albumin,
by gravity feed, you do not require a pumping system.
All standard off the shelf equipment/disposables and off the shelf 5% albumin.
You will achieve diluting your whole systemic blood supply.
All for less than $500.00{500ml 5% albumin, evacuated bottle to remove blood, infusion line set,
catheter/winged infusion set, blood removed line] as a do it yourself biohack.
Yes, “clinics” charging $2,500.00 per treatment and up will not like ithis.
This entire conversation is totally experimental.
Shamelessly copying from Blagosklonnys paper;
“If you wait until you are ready, it is almost certainly too late.” ~ Seth Godin
Shall we start a skunk works?
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What are the biological markers being measured by Conboy?
The meme appeal of younger blood being transfused is the reason I think it’s still talked about. But it’s encouraging that the research seems to suggest most of the benefit is removing the “bad stuff” from old blood vs adding special “good stuff” from young blood.
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What if instead of albumin, saline is injected? Same dilution. Is adding albumin a necessary part of the process?
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Thanks for posting. Very interesting. And its good to hear about the good results you’ve been seeing in patients.
Doing a little research on this company (and it may be true for the entire plasmapheresis equipment market), they lock you into their platform and then make very high margins on the “consumables”… this is a common business strategy, but from a customer standpoint is far from ideal as there is no price competition on the “consumables”. This is one strategy to raise the “barriers to entry” for potential competitors in this market, but it can also creates a market opportunity for lower priced, standardized equipment. I wonder if any companies are addressing this market. Years ago a company started manufacturing Hewlett Packard - compatible printer cartridges to get around the same issue / business strategy… this was a big, ongoing battle, I’m not sure how it eventually got resolved: HP is blocking third-party printer ink again - The Verge
As they mentioned in this stock analysis site:
Business Model
Haemonetics designs and manufactures blood collection systems, blood processing systems, devices incorporated in blood transfusions and cell processing, as well as related software. It employs a razor + blade model, where Haemonetics sells its customers’ plasma collection machines and associated consumables.
Competition
Haemonetics’ key competitors include Diagnostica Stago, Fresenius (FMS), Instrumentation Laboratory (Werfen), LivaNova (LIVN), MacoPharma, MAK-System, Medtronic (MDT), MSoft, Sysmex, Terumo (OTCPK:TRUMF), and WellSky.
In the automated plasma collection market, it principally competes with Fresenius’ Fenwal Aurora and Aurora Xi product lines on the basis of speed, plasma yield per donation, quality, reliability, ease of use, services, and technical features of the collection systems and on the long-term cost-effectiveness of equipment and disposables.
In the Blood Center, most donations worldwide are traditional manual whole blood collections and approximately 30% of the Blood Center portfolio competes in this space. There is intense competition in the whole blood business on the basis of quality and price. Main competitors are Fresenius, MacoPharma, and Terumo.
TEG systems compete more directly with other advanced blood test systems, including ROTEM analyzers, VerifyNow System and HemoSonics Quantra. ROTEM and VerifyNow instruments are marketed by Instrumentation Laboratory, a subsidiary of Werfen, and HemoSonics is owned and offered by Diagnostica Stago. In cell salvage, the intraoperative autotransfusion market, competition is based on reliability, ease of use, service, support, and price. For high-volume platforms, each manufacturer’s technology is similar and Haemonetics Cell Saver technology which competes principally with products offered by LivaNova, Medtronic, and Fresenius.
Market Share
In Plasma collection, Haemonetics has the leading market position with 75% of the U.S. market for machines and disposables:
Source: SeekingAlpha: https://archive.ph/rHg6M
Interesting equipment details:
The FDA 510(k) Summary: https://fda.report/media/142820/BK200498-Summary.pdf
The IMPACT Clinical Trial Validation Study (FDA filing): https://clinicaltrials.gov/ProvidedDocs/23/NCT04320823/Prot_001.pdf
The Research Study published as a result of the above “IMPACT” validation study: https://onlinelibrary.wiley.com/doi/pdf/10.1111/trf.16389
The Hemonetics PCS2 Operators Manual: http://www.frankshospitalworkshop.com/equipment/documents/automated_analyzer/user_manuals/Haemonetics%20PCS2%20-%20Operation%20manual.pdf
Corporate Annual Report: https://stocklight.com/stocks/us/manufacturing/nyse-hae/haemonetics/annual-reports/nyse-hae-2021-10K-21965962.pdf
Company overview presentation for Morgan Stanley: https://haemonetics.gcs-web.com/static-files/b56e06b2-ffa4-4a52-ab7b-9d94322139e8
Which of these is the type of equipment that one might want to purchase for home plasmapheresis?
You mentioned there are different machines for “collection” of blood / plasma, so there must be one for the “distribution” (replacement?) of the plasma. Can you help us identify what equipment is the “plasma replacement” products from these manufacturers?
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Baxter’s TPE Educational Presentations (videos and pdfs of slides below):
Part 1: TPE Part I: Methods, Goals & Guidelines
Part 2: TPE Part II: Treatment Considerations
TPE_Customer_Presentation_Pt1_2.pdf (612.0 KB)
TPE_Customer_Presentation_Pt2_0.pdf (622.4 KB)
FWIW
I prefer/have used{on my self] Ringer’s lactate solution, you may as well add some other compounds/molecules; magnesium chloride, vitamin C, just about any compounds/molecules is available in a form for IV use. The one’s that are not, you can have compound by a pharmacy.{Pharmacy than make IV compounds]
Would cost you less than $100.00 per infusion, depending on what you put in the IV solution.
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A quick reply, the “cell saver” are used{designed to be used] for collecting a patient own blood during surgery as to not use “blood donation” for replacement. The cell save is used to collect the blood, wash the blood and reinfuse.
Any piece of of equipment can be reconfigured for other use, “off label/approved” use.
I also used Ringers solution. It’s the only one I can use having transplanted kidney. How critical is albumin when diluting blood (for anti-aging purpose)?
This question should be addressed to RapAdmin {the people where he is in the trial] and or Conboy.
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MHO, the main issue is that we don’t actually understand what is happening. Like as not, there are only a few molecules that matter in the plasma. It’s inefficient & potentially dangerous to just dump someone else’s plasma into one’s body, leaving aside the difficulty of getting it.
In other words, I think the big target is the science. What is added, what is removed, why does it make a difference? If we knew that, we would be in a much better position to design a system to apply a meaningful therapy.
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I was hoping that Dr Harold Katcher’s work would result in a way to avoid all of this, but I haven’t seen any updates from him in a long time.
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I’m a bit confused as to why there’s still such lack of certainty about what is ideal — young blood transfusion or plasma dilution. This study from 2020 is what first got me started down the life extension rabbit hole and what really tickled my fancy was the conclusion that there’s nothing superior about young blood, but rather it was all a matter of flushing out old blood.
So why are we still debating which is better? Also all was needed was saline with 5% albumin so the cost of the consumables should be negligible. The only issue would be access to the machinery and training as a nurse to self inject.
Am I missing anything?
In the study, the team found that replacing half of the blood plasma of old mice with a mixture of saline and albumin — where the albumin simply replaces protein that was lost when the original blood plasma was removed — has the same or stronger rejuvenation effects on the brain, liver and muscle than pairing with young mice or young blood exchange. Performing the same procedure on young mice had no detrimental effects on their health.
This discovery shifts the dominant model of rejuvenation away from young blood and toward the benefits of removing age-elevated, and potentially harmful, factors in old blood.
“There are two main interpretations of our original experiments: The first is that, in the mouse joining experiments, rejuvenation was due to young blood and young proteins or factors that become diminished with aging, but an equally possible alternative is that, with age, you have an elevation of certain proteins in the blood that become detrimental, and these were removed or neutralized by the young partners,” said Irina Conboy, a professor of bioengineering at UC Berkeley who is the first author of the 2005 mouse-joining paper and senior author of the new study . “As our science shows, the second interpretation turns out to be correct. Young blood or factors are not needed for the rejuvenating effect; dilution of old blood is sufficient.”
Has Conboy since reversed course?
You’re right. The two notions, (1) dilution of plasma and (2) replacement of old plasma with young plasma have gotten a little mixed up in this thread. I think the Conboys are still betting on dilution - replacement of plasma with saline and a little albumin, adding nothing else. The trial RapAdmin was in did it this way.
However, there’s Harold Katcher’s isolation of some plasma factors that have been conserved across species. Using adolescent pig’s blood as the source of these factors, he has increased the health and lifespan of rats - no dilution was involved in his procedure.
As I’ve heard others speculate, maybe a combination of plasma dilution and addition of Katcher’s factors would work better than either alone.
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