What are your lowest risk longevity drugs and supplements – and at what dosage, and why? These are drugs with the highest reward to risk ratio, or highest risk-adjusted expected benefit.
Drugs for expected disease prevention or expected longevity benefit. You can also list lifestyle or other interventions here as well as long as it seems to approximately fit the criteria.
A good question. Are there any “no brainers”? I don’t take anything for ONLY longevity. Everything has a near term benefit (real or imagined).
For me, my no questions asked list:
Alleviating or preventing a vitamin or mineral deficiency with food or supplements is that. I think exercise is as well, and, a healthy diet, as we have so much association data for that and even clinical trials.
Creatine is well studied. I’d have to look at taurine and glycine.
I wonder if ezetimibe would qualify @adssx
And the same for low dose rapamycin.
I am trialing low dose naltrexone. If the research is correct, it has many positive effects. Most of them around lowering systemic inflammation.
I’ve cut my daily supplements down quite a bit over the last year . . . I’m now only taking stuff that has good data supporting efficacy. Not taking as many pills (first four on this list are powder that I mix with water every morning):
Daily:
Taurine: 10 g
Glycine: 9 g
Creatine Monohydrate: 5 g
Psyllium Fiber: 4 g
Metformin: 1000 mg
Tadalafil: 5 mg
Atorvastatin: 10 mg
Vitamin B12: 1000 mcg
Vitamin D: 3000 mg
Magnesium L-Threonate: 1300 mg
Lithium Orotate: 5 mg
Weekly:
Rapamycin: 7 mg
Semaglutide: 0.25 mg
You may want to see if these should be taken at the same time or if they compete. @DeStrider did you say something about that?
Yes. Based on what I’ve read, Glycine and Taurine both use the Glycine Receptor to be absorbed and used by your body. Glycine has a preference over Taurine. If the amino acids are not absorbed fast enough, the remaining are sent to your waste. I would separate taking these two amino acids by at least 2 hours to get maximum absorption otherwise you may not be absorbing much Taurine (if any).
Also, it is best to take amino acids on an empty stomach as the amino acids in food also compete for absorption.
@DeStrider: I’ve heard you say before that they both ‘compete’ for the glycine receptor; maybe you’ve posted a reference to a study before that I’ve missed. Can you repost? Thanks!
What’s “low dose”? Too low might be dangerous: Top 5 - Which Currently Available Longevity Interventions Do You Think Are the Best - #201 by Jonas
I’d say supplement-wise, Taurine, Astaxanthin, Creatine, Collagen, Glycine, Hyaluronic Acid, micro dose Melatonin (even though it’s really a hormone), and Magnesium are pretty beneficial and extremely low risk for virtually everyone.
I will leave out things previously mentioned here, but the one being left out is Pectasol. It helps with heavy metal burden and blocks galectin 3. So should help with cancer and heart disease. Take on an empty stomach. This is just modified citrus pectin.
Also Lutein and zeaxanthin. Or goji berries.
Vaccines (influenza, HPV, zona, BCG, etc.) are bar far the safest, most effective, and most proven intervention. Way better than anything mentioned in this thread so far.
What is Zona? I know of the rest
Shingles, also known as herpes zoster or zona.
Sauna if used regularly:
I’m going to have to look into Pectasol. I’ve never even heard of it but those are big benefits if true.
https://www.wellesu.com/https://doi.org/10.1159/000109829
The introduction is very good reading. This thread is about things that are safe though, and I don’t see how it could be safer than citrus pectin.