Hi everyone, I’ve noticed my Alkaline phosphate is below normal. For the past 18 months I have been taking 3mg of rapamycin with 8 ounces of grapefruit juice so 9 all together. My AST and ALT are normal. Globulin is 1.7 and should be at least 2. Could Rapa be affecting my markers in this way. Ty
Low ALP is a good thing, younger people have lower ALP. You don’t give a value. Is it 60?
What is your current measure?
This is from CGPT5:
Prompt: What are the optimal levels for longevity of the blood marker for Alkaline phosphate (ALP)?
Response:
Great question — alkaline phosphatase (ALP) is a routine liver/bone enzyme that also has been studied as a biomarker of aging, mortality risk, and longevity. The “optimal” level for longevity is not simply the lowest possible (like with CRP or fasting insulin), but rather within a moderate, healthy range.
1. General Reference Ranges
- Clinical “normal” reference range: ~30–120 U/L in most labs (varies slightly).
- These are designed to detect overt disease, not necessarily optimize for longevity.
2. ALP and Mortality Risk (Population Data)
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Higher ALP = higher mortality risk:
- Multiple large cohorts (NHANES, UK Biobank, Japanese population studies) have shown that ALP above ~90–100 U/L is associated with higher risk of all-cause and cardiovascular mortality, independent of liver disease.
- Example: In a 2020 study of >9,000 adults, individuals in the highest quartile (>90–100 U/L) had a ~1.5–2× increased risk of death compared with those in the mid-normal range.
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Very low ALP may also be concerning:
- Levels consistently below ~30 U/L can indicate hypophosphatasia, zinc/magnesium deficiency, or malnutrition.
- Low-normal levels in healthy individuals, however, are not strongly linked with increased mortality.
3. Biological Mechanisms
- ALP is linked to vascular calcification and bone metabolism.
- Higher ALP is associated with inflammation, oxidative stress, and frailty in older adults.
- In CKD patients, high ALP correlates with worse outcomes (vascular calcification, bone turnover, mortality).
4. Optimal Range for Longevity (based on observational data)
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Sweet spot appears to be mid-normal, roughly ~40–70 U/L.
- Below ~40: can be benign in healthy people, but persistent very low values warrant checking micronutrient status.
- Above ~80–90: progressively higher risk for cardiovascular disease, frailty, and all-cause mortality.
- Consistently >100: often considered a red flag for hidden liver, biliary, or bone pathology.
Longevity-oriented target (practical takeaway)
- Optimal ALP for longevity: approximately 40–70 U/L.
- Sub-optimal: <30 (possible deficiency/disease) or >90–100 (higher mortality risk).
- As with all markers, context matters: ALP should be interpreted along with liver enzymes (ALT, AST, GGT), bone health labs (calcium, vitamin D, phosphate), and inflammatory markers (CRP).
I’m 70 and my ALP is consistently been 25
You need to look at ALP in the context of other biomarkers.
I’ve always had the same problem and can’t figure out a way to raise it. Mine was 39 last time and always below the reference range. I don’t know whether I should care or not.
Generally, zinc and magnesium deficiency are common causes but I consume plenty of both so I’m not sure what to think of my low level. Hypothyroidism can also be a contributing factor.