looking to add something to my rapacan dosage for longevity, The only other thing I take related to that is Resveratrol (when I can remember to take it, for some reason i tend to forget). My blood sugar is border line (96-110) and my A1C was 5.5 last check and 5.6 previous. (usually checked once/yr). I see here many use metformin. what dosage? 500? any suggestions to add to rapacan?
thx
Metformin/Acarbose/SGLT2I - choose 1 or multiple. I use all 3. ITP results showed Metformin and Acarbose taken with Rapamycin is additive to longevity.
LLTs - statin or BA+Ezetemibe. I take all 3. Pitavastatin if you import it.
Agree - sugar and lipids.
Only other major is blood pressure which you didn’t mention.
My extra meds
Sugar - acarbose, Jardiance.
Lipids - lipitor, Zetia
BP - talmisartan
Goals are all somewhat debatable but
A1C<5, LDL<70, MAP 70-75 are reasonable. A1C doesn’t tell the whole story and acarbose probably helpful even if A1C isn’t changed much.
Personal history and genetics could change goals especially LDL. I have a friend at 17 because of his family history and CAC. At this goal based on academic MD recommendations - not a fringe concept.
If you go with mouse data - acarbose wins. But mice don’t have BP or lipid concerns so lipids probably most important for average person (assuming BP and A1C is at least normal range).
