looking to add something to my rapacan dosage for longevity, The only other thing I take related to that is Resveratrol (when I can remember to take it, for some reason i tend to forget). My blood sugar is border line (96-110) and my A1C was 5.5 last check and 5.6 previous. (usually checked once/yr). I see here many use metformin. what dosage? 500? any suggestions to add to rapacan?
thx
Metformin/Acarbose/SGLT2I - choose 1 or multiple. I use all 3. ITP results showed Metformin and Acarbose taken with Rapamycin is additive to longevity.
LLTs - statin or BA+Ezetemibe. I take all 3. Pitavastatin if you import it.
Agree - sugar and lipids.
Only other major is blood pressure which you didn’t mention.
My extra meds
Sugar - acarbose, Jardiance.
Lipids - lipitor, Zetia
BP - talmisartan
Goals are all somewhat debatable but
A1C<5, LDL<70, MAP 70-75 are reasonable. A1C doesn’t tell the whole story and acarbose probably helpful even if A1C isn’t changed much.
Personal history and genetics could change goals especially LDL. I have a friend at 17 because of his family history and CAC. At this goal based on academic MD recommendations - not a fringe concept.
If you go with mouse data - acarbose wins. But mice don’t have BP or lipid concerns so lipids probably most important for average person (assuming BP and A1C is at least normal range).
at what dose?. (Metformin/Acarbose/SGLT2I )
I’ll add i do take ezetimibe and rosuvastatin as my chol is genetically high. I don’t take BP meds specifically for BP control any longer as I exercise nearly every day and lost 40+ lbs over the past yr or so. I do take three of them off-label for other reasons (control of heart skip, night terrors and my Doc likes lisinopril for my kidneys) but they are all at very low doses. 1.25 mg each accept the prazosin at 5mg. My CAC 3 yrs ago (at 64yrs old) was 42 and now I’m taking 12,000FU’s of nattokinase to see what that does for plague.
I take Metformin 500 mg at night, Acarbose 100 mg at meals, and 10 mg Dapagliflozin in the morning.
do you take metformin sr or regular? the regular can be split for cost savings but the sr is not supposed to be split from what I understand. also, i wonder if you could dose every other night and still have a good control of BS? (not that mine is really bad). I noticed that mine went up went I started rapacan.
I take Metformin XR and do not split it. It comes in 500 mg. Rapamycin can increase LDL/ApoB and blood sugar. It does for me.