looking to add something to my rapacan dosage for longevity, The only other thing I take related to that is Resveratrol (when I can remember to take it, for some reason i tend to forget). My blood sugar is border line (96-110) and my A1C was 5.5 last check and 5.6 previous. (usually checked once/yr). I see here many use metformin. what dosage? 500? any suggestions to add to rapacan?
thx
Metformin/Acarbose/SGLT2I - choose 1 or multiple. I use all 3. ITP results showed Metformin and Acarbose taken with Rapamycin is additive to longevity.
LLTs - statin or BA+Ezetemibe. I take all 3. Pitavastatin if you import it.
Agree - sugar and lipids.
Only other major is blood pressure which you didn’t mention.
My extra meds
Sugar - acarbose, Jardiance.
Lipids - lipitor, Zetia
BP - talmisartan
Goals are all somewhat debatable but
A1C<5, LDL<70, MAP 70-75 are reasonable. A1C doesn’t tell the whole story and acarbose probably helpful even if A1C isn’t changed much.
Personal history and genetics could change goals especially LDL. I have a friend at 17 because of his family history and CAC. At this goal based on academic MD recommendations - not a fringe concept.
If you go with mouse data - acarbose wins. But mice don’t have BP or lipid concerns so lipids probably most important for average person (assuming BP and A1C is at least normal range).
at what dose?. (Metformin/Acarbose/SGLT2I )
I’ll add i do take ezetimibe and rosuvastatin as my chol is genetically high. I don’t take BP meds specifically for BP control any longer as I exercise nearly every day and lost 40+ lbs over the past yr or so. I do take three of them off-label for other reasons (control of heart skip, night terrors and my Doc likes lisinopril for my kidneys) but they are all at very low doses. 1.25 mg each accept the prazosin at 5mg. My CAC 3 yrs ago (at 64yrs old) was 42 and now I’m taking 12,000FU’s of nattokinase to see what that does for plague.
I take Metformin 500 mg at night, Acarbose 100 mg at meals, and 10 mg Dapagliflozin in the morning.
do you take metformin sr or regular? the regular can be split for cost savings but the sr is not supposed to be split from what I understand. also, i wonder if you could dose every other night and still have a good control of BS? (not that mine is really bad). I noticed that mine went up went I started rapacan.
I take Metformin XR and do not split it. It comes in 500 mg. Rapamycin can increase LDL/ApoB and blood sugar. It does for me.
I’m going to contact jagdish and see if I can get all 3 from him. I know he has metformin. I see dapagliflozin comes in 5 and 10mg. I wonder if I need 10mg? maybe I could get 10mg and split them at 5mg to start?
jagdish came back to me with acrarbose (glucobay) 25 or 50mg tabs. is your 100mg one tablet or are you taking more than one to equal 100mg?
Acarbose blows Metformin out of the water if you’re looking for general longevity.
Apparently a number of people take both. I was looking at possibly doing that also. one contributor said " ITP results showed Metformin and Acarbose taken with Rapamycin is additive to longevity."
But I wouldn’t mind just taking one of them either. less cost and less to keep on my cluttered countertop 
Acarbose destroyed metformin in the ITP results. Metformin did not show any lifespan extension, unless it was combined with Rapamycin. Acarbose and rapamycin combined had the greatest results in the ITP.
But yes, you can use both if you want
I don’t necessarily want to. I would prefer taking just one. However i would also prefer to take what has the best benefit towards longevity. The issue for me; is there is so much info. out there it’s hard to make a decision. (eggs are bad, eggs are good, coffee is good, coffee is bad…) If you go to the top of this thread you will see i started it by asking the forum a question.
sorry for the late reply. My BP is fine and my resting HR is in the high 40’s very low 50’s. I exercise every day unless sick and that hardly ever occurs.
In a previous ITP study, a dose of 1000 ppm metformin extended the median lifespan of male mice by 8%. However, this effect did not reach statistical significance using the log-rank test. But when researchers at the renowned Barshop Institute for Aging Research reanalyzed the ITP data using the Gehan test, they found a significant increase in survival among metformin-treated males.
Many people may not fully understand this, so here’s a brief explanation: the Gehan test is more sensitive to differences in mortality rates early in life, and it does not assume a uniform reduction in mortality risk across the entire lifespan. In fact, it is a better approach than the log-rank test. This suggests that metformin is indeed effective. I originally thought about posting the paper, but decided against it, since most people are put off by academic papers—at most they might read the abstract or use AI to produce factually distorted analyses. For those interested, further self-study is encouraged.
I bought 100 mg Acarbose tabs. I bought them either from Jagdish or Maulik. I can’t remember now.
Acarbose’s therapeutic index is probably way superior too… At 10,000ppm metformin is already toxic in mice and shortens their lifespan.
But I also just don’t like metformin based on general principle (it’s a Complex I inhibitor).
Think about it like this: Our bodies have to dissipate energy to maintain their structure. The electron transport chain provides ~90% of that energy, and provides it in a highly selective way, with very little coupling to reactive species generation. So to go and block it in a healthy person is really quite unsophisticated.
But it gets confusing for people because excessive metabolic flux is obviously toxic and drives aging, in which case pushing the aforementioned pathways too hard can lead reductive stress. But that’s probably a small thing compared to associated accumulation of lipid in the arteries and other non-adipose tissues, accelerated glycation throughout the body, and excessively driving the cell growth pathways which are coupled to energy status.
Anyways, I don’t want to get off topic too much. Empagliflozin, ezetimibe, and dutasteride are the clear winners for me alongside rapamycin. If I could tolerate acarbose it would probably be there too.