Longevity Scientist Breaks Down What Causes Aging of Cells - Matt Kaeberlein

#1

Another excellent explanation on cells and aging for the lay person. Matt Kaeberlein identifies a couple items that catch my interest.

One is the 15% increase in life span of the marmoset study should get anyone looking at rapamycin for humans excited. And twice he warns of too much rapamycin (a higher dose) might affect senescent cell and immunity for life span in a positive direction while being harmful in other biological areas as a negative issue. He states this about 2/3rds in… and then again cautions on high dosing rapamycin. Perhaps it is through MTOR2 being altered.

I personally have had this happen… higher doses caused negative biological issues. Moderate dose 6mg had positive benefits.

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#2

Yes. The dosing issue is the key here. How much how often. I find that 7 mg + GFJ + fat (24 mg equivalent) causes incredibly itchy hives to break out all over my body for a few days, so I’m moving back to 5-6 mg + GFJ + fat (17-21 mg equivalent).

At least now I know my limit. Fortunately it appears Rapa doesn’t affect my LDL or ApoB incrementally at high doses. Although it did bump my LDL and ApoB by 50 points (dose independent) which I countered with meds.

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#3

how frequently do you take this?

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#4

I’m taking it either 1X a week (5 mg + GFJ) or 1X every 2 weeks (6 mg + GFJ).

My blood biomarkers are all good except for HBA1C (5.8). Not sure if it’s the Rapa or crap vacation diet that’s the cause (restaurant food in excess). I’ll find out at my next blood test in 6 months.

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#5

Just modified our Rap process. Been taking 6mg every 2 weeks for about 2 years. With GFJ + EVOO.

Just added 3mg to the “between week” without GFJ but with EVOO.

Been thinking that with the half life, it might be good to have a bit more in the system instead of letting it run all the way down.

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