Covered a lot of topic with practical tips on C15, Rapamycin, Ozone, NAD, and Peptides.
Also, one of rumors from Oracle employees is that Larry Ellison sleeps in hyperbaric chamber which is also discussed in the video.
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He lost me at âFatty15 is looking better than rapamycin for longevityâ. Oh, reallyâŚ.bye bye.
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This would be really interesting, if true. He does look pretty good for an 80 year old man.
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He is saying rapamycin stays in your body for 10 days with half life being 60 hours, so he recommends doing rapamycin every other week or every 3rd week, FWIW. And he loves all Peptides.
The âExpertâ is wrong, single doses of Rapamycin have a half life maximum in the mid 30 hr range, and for some people a bit shorter. It is only daily dosing that generates that half life.
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Self proclaimed âExpertâ.
All these internet influencer are self proclaimed âExpertâsâ.
Majority have no real /true understanding of what they speak / post about.
Bernays methodology currently at it finest.
Wait till AI is in full operation.
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An 80 year old with unlimited resources.
âAs of September 2024, Ellisonâs net worth has reached an astounding $206 billion , according to Forbesâ real-time billionaire rankingsâ
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Money is not everything, look at Bill Gates, who is only 68, even richer.
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Do you really think that the âgeneral publicâ knows what the ultra wealthy do for their personal health?
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FWIW
Forbes pegged his net worth at $107 billion, putting him at No. 12 among worldwide billionaires.
Due process. I listened to some before judging on those sections.
Good sections are âBest Exercisesâ and Mitochondrial Testing. His cardiology background shows in the exchange on best exercises, and VO2 max.
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My dad is 92 and looks younger that depopulation Bill.
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This is a strange claim. Where do you get the mid 30 hr range? Are you counting the initial drop from the peak or the half-life later? The half life is very fast in the first hours after it reaches peak concentrations, but when it has stabilized after the drop from the peak (which will have occurred after 24 hours or so) the half-life is much slower. The half-life after 24 hours becomes around 60 hours with single doses. Btw I have measured my blood levels after 48 and 72 hours and calculated based on my levels at these time points that my half-life is very close to 60 hours.
Itâs not so much a claim, it is just what my patientâs data has demonstrated. The populations where the data is primarily gathered are often on a lot of different things, also chronically unwell, and doing daily dosing. ePocrates used to list single dose metabolism as 35 hrs, they have since dropped that and just list pharmacology on standard dosing daily.
The data given in my example is real data, and is consistent with my other patients where most end up being in the mid 30âs-40âs of hours for T1/2.
The population is likely different from the folks in the trials establishing T1/2 of 62 or 65 hours.
The math is straight-forward as listed in my description. By 48 hours after my 20 hour level, I had less than 1/2 the serum level of sirolimus. So the T1/2 is <48 hours.
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I recall Matt Kaerberlein, who knows a thing or two about rapamycin, mentioned a much shorter half-life on one of his podcasts. Single digit hours.
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I find that very odd that your patientâs data give such a short half-life and I donât think the difference lies in the populations form which the data is gathered being form people that are unwell or taking lots of drugs. How then do you explain this study, which found a half-life over 60 hours in healthy young adults taking single doses of rapamycin? Pharmacokinetics and safety of single oral doses of sirolimus (rapamycin) in healthy male volunteers - PubMed
This might explain why youâre getting shorter half-lives. Youâre measuring the first blood test at 20 hours, which is a time point at which levels are still dropping from the peak and just before levels have stabilized more. If you were to measure at 48 hours and then later you would likely get a half-life much closer to 60 hours. See Figure 1 in the full text of the study I referred to above.
They are fully distributed by 20 hours and it isnât too soon to measure. Irrespective, we have a good understanding through this method of time above 3.0 ng/mL which is the important question I want to answer, and through this methodology, it answers that question well.
@Peterz54 Matt Kaeberlein unfortunately had an error in methodology in that he was intermingling absorption before redistribution to get his peak level and then started at that point to compute T1/2, but the problem was most of the drop wasnât metabolism, it was tissue redistribution as rapamycin has a large volume of distribution. Having done a lot of graduate pharmacology, this isnât necessary obvious to those who are just doing the math and the levels. Itâs got to be fully redistributed before one can look at purely the metabolism. I suspect Mattâs T1/2 based on his data is in the mid 30âs or even a bit more brisk.
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Thanks for the info. Assuming youâre right in that itâs fully distributed by 20 hours (which I can believe) that still leaves out some explanation for why the half-life of your patients is considerably shorter than that found in the above study on healthy young adults. Are you having these patients test at 20 hous and 48 hours like you did for yourself, and then calculating the half-life based on the numbers at these time points? Have you seen this in large enough group of patients to be fairly confident in this (10+ patients)?
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Yes the range has been mid 30âs to mid 40âs of hours. Itâs a pain to get 2 blood draws close together. I have more patients opting for a 20 hr and then putting T1/2 around 40 hours. If I can get them to do both, that is useful and adds to my knowledge on this.
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Thanks. I like your strategy. Itâs similar to what I would do if I were a doctor with patients.
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