Longevity Breakthroughs of 2022

A good scientific summary.


The papers she based her presentation on, are listed in the original youtube site, as follows:

Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration - https://doi.org/10.1126/sciadv.abj2164

Moiseeva, V., Cisneros, A., Sica, V. et al. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature (2022). https://doi.org/10.1038/s41586-022-05…

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - https://doi.org/10.1016/j.ebiom.2022…

Selenium mediates exercise-induced adult neurogenesis https://doi.org/10.1016/j.cmet.2022.0…

A rare human centenarian variant of SIRT6 enhances genome stability - https://doi.org/10.15252/embj.2021110393

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming https://doi.org/10.7554/eLife.71624 Papandreou, ME., Konstantinidis, G. & Tavernarakis,

N. Nucleophagy delays aging and preserves germline immortality. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00… Kriebs, A. Body temperature not metabolic rate modulates lifespan. Nat Aging 2, 368 (2022). https://doi.org/10.1038/s43587-022-00…

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases - https://doi.org/10.1101/2021.11.01.46… Snyder, J.M., Casey, K.M., Galecki, A. et al.

Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice. GeroScience (2022). https://doi.org/10.1007/s11357-022-00…

Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus - https://doi.org/10.15252/embr.202255299 Browder, K.C., Reddy, P., Yamamoto, M. et al.

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nat Aging 2, 243–253 (2022). https://doi.org/10.1038/s43587-022-00…


The Sirt6 paper got me reinterested in this publication, and its table of natural Sirt6 activators:


“A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes”