Live to 100? How about 1,000? Why this scientist believes we will one day have lifespans that long

The author of the article underestimate the longevity benefits (its about 30% lifespan improvement seen in mice, and upwards of 37% when combined with Acarbose). At this point, I’m surprised the writers still get the basics wrong on rapamycin.

De Magalhães acknowledges that when it comes to finding an ageing “cure”, it’s likely that we’re never going to have a penicillin-like drug.

Instead, he highlights a compound called rapamycin, also known as sirolimus, that could be a key to quasi-immortality. In lab studies, it has extended the lifespan in animals such as mice by 10 to 15 per cent.

Rapamycin enhances autophagy, a process that removes unnecessary, abnormal and damaged components within cells and prevents cells from stress. It is used to treat some cancer patients – it stops cancerous cells from growing and multiplying.

This is why it holds promise in slowing cell degeneration – a key contributor to ageing, de Magalhães says.

(of course, the paper goes off on a tangent describing the worst side effects at the highest doses).

More info:


It’s hard to trust any article that has such glaring errors.

1 Like

Yes, but I always try to contact the authors and move them in the right direction… John Mac Ghlionn is on twitter:


If you live to 1000, what is retirement age? I’m not looking forward to working for 800 years.

Hopefully your capital will be working for you so you don’t have to.

1 Like