Lifespan: Rapamycin started early in life vs late in life

#1

Is there any studies compared lifespan if rapamycin treatment is started early, middle and late in life?

#2

I believe one of the more robust studies on rapamycin in mice life extension was treatment started at 9 months old (im assuming they continued the treatment throughout life). 9months maybe similar to human in their 30s? not sure.
Since Rapa affects a type of nutrient signaling in a more scarcity direction, in theory the earlier would give more time to reduce the accumulation of damage or detrimental aging factors.

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#3

Interesting, do you have the link to the study?

#4

This is what I have found now which shows quite similiar effects in mean and max lifespan. Little better overall if started early but not much.

Early started 270 days (around 30 years in human)
Mean lifespan: 10% male, 18% female
Max lifespan: 16% male, 13% female

Late started 600 days (around 60 years in human)
Mean lifespan: 9% male, 13% female
Max lifespan: 9% male, 14% female

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#5

Yeah this is the one Im referring to as theres multiple studies that start rapa at 9 months age. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction - PubMed the results were 23%(male) 26%(female) increase in median lifespan

Ive also saw that reduction of BCAA intake (alternative way to mtor inhibition) is especially effective in male mice at extending lifespan. Which makes sense because things like dietary meat probably raises anabolic pathways in males a lot.

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#6

Here is another one on heterogeneous mice

Early started 270 days (around 30 years in human)
Dose: 14 ppm
Mean lifespan: 13% male, 21% female
Max lifespan: 8% male, 11% female

The optimum dose is more likely higher than 14 ppm. Here are two studies with higher doses on heterogeneous mice. Here we see a bigger impact on mean lifespan if treatment is started early.

Early started 270 days (around 30 years in human)
Dose: 42 ppm
Mean lifespan: 23% male, 26% female
Max lifespan: 8% male, 11%

Late started 600 days (around 60 years in human)
Dose: 42 ppm
Mean lifespan: 11% male, 15% female
Max lifespan: 9% male, 12% female

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