You were referring to this sentence, perhaps?
“CR targets nutrient-sensing pathways centering on mTORC1. The mTORC1 inhibitor, rapamycin, is considered a potential CR mimetic and is proven to counteract age-related muscle loss.”
You were referring to this sentence, perhaps?
“CR targets nutrient-sensing pathways centering on mTORC1. The mTORC1 inhibitor, rapamycin, is considered a potential CR mimetic and is proven to counteract age-related muscle loss.”
It looks like LPD (low protein diet) also inhibits mTORC1.
“Nutritional interventions, such as a LPD, also suppress mTORC1 because AAs (amino acids) promote mTORC1 activation.”
@JuanDaw Exactly, although LPD and CR can both lower mtor, the effect of CR is broader and so quite different overall.
The ironic thing is I was already quite familiar with the study Arhu linked beforehand.
We also compared the amino acid concentrations of patients who recovered and those who expired. The results are shown in Table 4. The mean of amino acids alanine, arginine, glycine, isoleucine, and serine was lower in patients who have expired. Low level of glutamine and isoleucine was seen in 57% and 86% of expired cases, respectively. Logistic regression analysis (95% confidence interval) was performed to determine the risk of admission to ICU and mortality prediction, and just isoleucine was considered a predictor variable in mortality (P = 0.02, EXP (B) = 16.5, and CI 95% = (1.48, −183.07)), and its decrease in patients was associated with an increase in mortality.
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Another finding of our study was the low level of Isoleucine as predictor variable for mortality. In 42% of our patients, isoleucine was less than 30uM (RI = 30-130 uM), and the mean of ileu was even lower in the ICU-patients and the expired (28 and 21 μM, respectively). The role of branched chain amino acids was investigated in several studies. Muendlein et al. [17] in their study reported low serum valine and leucine levels as mortality predictors in patients with established CVD. Gu et al. [18] in a review article has investigated the role of isoleucine in maintaining the immune system and reduction of rotavirus infection following administration of L-isoleucine in the piglet model. Attenuation of E. coli infection by isoleucine through the modulating antimicrobial peptide expression as well as its effect on plasma level of endotoxin and IL6 in weaned pigs also were reported [19]. However, more studies are needed on the role of branched chain amino acids, especially isoleucine, in the human immune system.