Keto diet may accelerate organ ageing (New Scientist)

#1

A ketogenic diet causes damaged cells to accumulate in the organs of mice. Their build-up suggests the keto diet may accelerate organ ageing, raising the risk of conditions like heart disease and cancer.

Although many people have adopted low-carbohydrate diets like keto for weight loss and controlling blood sugar, research on their health effects is mixed, with some studies finding they increase the risk of heart attacks.

Full article: Keto diet may accelerate organ ageing (New Scientist)

#2

They fed mice 90% Crisco — I’m not sure that’s a good representation of the keto diet. Too bad that the New Scientist article does not mention this.

However, it may be a good indicator about the health value of the incredients of Crisco, listed in their website as: “SOYBEAN OIL, HYDROGENATED PALM AND SOYBEAN OILS, MONO AND DIGLYCERIDES, TBHQ, CITRIC ACID.”

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#3

Here is the full paper:

Here, we show on two different KDs that mice accumulate senescent cells in the normal tissue of multiple organs. We chose these two different KDs, Crisco versus cocoa butter–based, because these two diets contain very different ratios of saturated versus unsaturated fatty acids. KD-induced cellular senescence was not age-dependent and was observed in mice put on a 21-day KD starting at 6, 16, 24, and 52 weeks of age. Mice on a KD showed elevated p53, mediated by phosphorylated adenosine monophosphate–activated protein kinase α (pAMPKα) and mouse double minute 2 (MDM2) inactivation through caspase-2 cleavage, leading to induction of p21 and cellular senescence. Markers of the senescence-associated secretory phenotype (SASP) were increased in mouse serum following a 21-day KD as well as in human plasma from individuals on a 6-month KD clinical trial at our institutions [University of Texas Health Science Center at San Antonio (UTHSCSA)]. Last, cellular senescence was prevented by administration of an intermittent KD (IKD) regimen. As cellular senescence has been implicated in the pathology of organ disease, our results have important clinical implications for understanding the use of a KD.

https://www.science.org/doi/10.1126/sciadv.ado1463

and Crisco:

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#4

Ah I see they also use cocoa butter-based diets.

I used to think this provided a healthier form of saturated fat, but maybe not at such high levels.

#5

aren’t those trans fats ?

#6

I suppose that fully hydrogenated oils are neither cis- nor trans- : they are saturated fatty acid esters.
Deemed to be unhealthy if large percentage of fat intake…

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